Early follow-up quality of life and mental health of patients with congenital vascular malformations cared for in a multi-disciplinary specialist centre

Abstract

Objective

The study aimed to evaluate the early follow-up quality of life (QoL), pain and mental health of patients with congenital vascular malformation (CVM) from a variety of treatment options.

Methods

All patients with CVM who received care and had follow-up between February 1st 2018 and January 31st 2020 were included. The health-related QoL, pain, and mental health were assessed with RAND Health Care 36-Item Short Form Survey (SF-36), visual analogue score for pain (VAS-P) and Hospital Anxiety and Depression Scale (HADS). Paired t-test was used for all analyses. p < .05 were considered significant.

Results

In total, 110 patients with a mean age of 36.9 years were included in this study. In all patients following care, significant improvement was found in the bodily pain domain of SF-36 and VAS-P (both p = .01). This was largely driven by high-flow vascular malformation patients who responded better to embolo-sclerotherapy, which revealed significant improvement in the bodily pain domain of SF-36 (p = .002) and VAS-P (p = .02). Patients who received supportive treatment only reported significant improvement in mental health (p = .004) and social functioning (p = .03) domains of SF-36. Meanwhile, patients treated with embolo-sclerotherapy reported significant improvement only in VAS-P (p = .02).

Conclusions

This study concluded that the effects of care on early follow-up QoL, pain and mental health of patients with CVM were heterogenous. Future research should therefore, include larger sample size and longer term follow-up to understand the various factors that affect the QoL and mental health of these patients, as well as the holistic approaches to manage them.

Keywords

Quality of life mental health patient outcome assessment vascular malformations arteriovenous malformations vascular malformations treatment

Get full access to this article

View all access options for this article.

References

Pang

Gibson

, et al. Quality of life and mental health of patients with vascular malformations in a single specialist center in the United Kingdom. Journal of vascular surgery. Venous and lymphatic disorders 2022; 10: 159–169.

Pang

Lim

Brookes

, et al. Emerging importance of molecular pathogenesis of vascular malformations in clinical practice and classifications. Vascular medicine (London, England) 2020; 25: 364–377.

Pang

Gibson

Nisbet

Pang

Lim

Brookes

, et al. Emerging importance of molecular pathogenesis of vascular malformations in clinical practice and classifications. Vascular medicine (London, England) 2020; 25: 364–377.

Pang

Gibson

Nisbet

Hand

Frieden

. Vascular birthmarks of infancy: resolving nosologic confusion. American journal of medical genetics 2002; 108: 257–264.

Folkman

. Fundamental concepts of the angiogenic process. Current molecular medicine 2005; 3: 643–651.

Boon

Mulliken

Vikkula

, et al. Assignment of a locus for dominantly inherited venous malformations to chromosome 9p. Human molecular genetics 1994; 3(9): 1583–1587.

Flye

Jordan

Schwartz

. Management of congenital arteriovenous malformations. Surgery 1983; 94(5): 740–747.

10.

Greene

Orbach

. Management of arteriovenous malformations. Clinics in plastic surgery 2011; 38: 95–106.

11.

Rautio

Laranne

Kähärä

, et al. Long-term results and quality of life after endovascular treatment of venous malformations in the face and neck. Acta radiologica (Stockholm, Sweden : 1987) 2004; 45(7): 738–745.

12.

Weitz-Tuoretmaa

Keski-Nisula

, et al. Quality of life after endovascular sclerotherapy of low-flow venous malformations: the efficacy of polidocanol compared with ethanol. Acta radiologica (Stockholm, Sweden : 1987) 2018; 59(8): 946–952.

13.

Pang

Gibson

Nisbet

14.

Health

Medical

Study

, et al. 36-Item Short Form Survey (SF-36) Scoring Instructions. Santa Monica, CA: RAND, 2016, http://www.rand.org/health/surveys_tools/mos/36-item-short-form/sco

15.

Hays

. The Medical Outcomes Study (MOS) measures of patient adherence. Santa Monica, CA: RAND, 1994.

16.

Bjelland

Dahl

Haug

, et al. The validity of the Hospital Anxiety and Depression Scale. An updated literature review. Journal of psychosomatic research 2002; 52(2): 69–77.

17.

Herrmann

. International experiences with the Hospital Anxiety and Depression Scale--a review of validation data and clinical results. Journal of psychosomatic research 1997; 42: 17–41.

18.

Snaith

. The hospital anxiety and depression scale. Health and Quality of Life Outcomes 2003; 1(1): 29.

19.

Ware

Snoww

Kosinski

, et al. SF-36 health survey: manual and interpretation guide. Boston, MA: The Health Institute, New England Medical Center, 2003.

20.

Ware

Kosinski

Keller

. SF-36 physical and mental health summary scales: a user’s manual. Boston, MA: The Health Institute, New England Medical Center, 1994.

21.

Queisser

Seront

Boon

, et al. Genetic basis and therapies for vascular anomalies. Circulation research 2021; 129: 155–173.

22.

Pang

Evans

Jethwa

, et al. Single center experience of sirolimus therapy in head and neck low-flow vascular malformations. Vascular and endovascular surgery 2021; 55(5): 482–490.

23.

Pang

Evans

Jethwa

, et al. Single center experience of sirolimus therapy in head and neck low-flow vascular malformations. Vascular and endovascular surgery 2021; 55(5): 482–490.

24.

Nadal

Giraudeau

Tavernier

, et al. Efficacy and safety of mammalian target of rapamycin inhibitors in vascular anomalies: a systematic review. Acta Dermato-Venereologica 2016; 96: 448–452.

25.

Freixo

Ferreira

Martins

, et al. Efficacy and safety of sirolimus in the treatment of vascular anomalies: a systematic review. Journal of vascular surgery 2020; 71: 318–327.

26.

Adams

Trenor

Hammill

, et al. Efficacy and safety of sirolimus in the treatment of complicated vascular anomalies. Pediatrics 2016; 137(2): e20153257.

27.

Veräjänkorva

Rautio

Giordano

, et al. The efficiency of sclerotherapy in the treatment of vascular malformations: a retrospective study of 63 patients. Plast Surg Int 2016; 2016: 2809152.

28.

Prasetyono

TOH

Kreshanti

. Efficacy of intra-lesional alcohol injection as alternative and/or complementary treatment of vascular malformations: a systematic review. Journal of plastic, reconstructive & aesthetic surgery : JPRAS 2010; 63: 1071–1079.

29.

Gemmete

Pandey

Kasten

, et al. Endovascular methods for the treatment of vascular anomalies. Neuroimaging Clinics of North America 2013; 23: 703–728.

30.

Vogelzang

Atassi

Vouche

, et al. Ethanol embolotherapy of vascular malformations: clinical outcomes at a single center. Journal of vascular and interventional radiology : JVIR 2014; 25(2): 206–214.

31.

Yakes

. Endovascular management of high-flow arteriovenous malformations. Seminars in interventional radiology 2004; 21(1): 49–58.

32.

Burrows

Mason

. Percutaneous treatment of low flow vascular malformations. Journal of vascular and interventional radiology : JVIR 2004; 15: 431–445.

33.

Kim

Park

. How to treat peripheral arteriovenous malformations. Korean journal of radiology 2021; 22(4): 568–576. Available from: https://pubmed.ncbi.nlm.nih.gov/33543847

34.

Horbach

SER

van der Horst

CMAM

Blei

, et al. Development of an international core outcome set for peripheral vascular malformations: the OVAMA project. The British journal of dermatology 2018; 178(2): 473–481.

Supplementary Material

Please find the following supplemental material available below.

For Open Access articles published under a Creative Commons License, all supplemental material carries the same license as the article it is associated with.

For non-Open Access articles published, all supplemental material carries a non-exclusive license, and permission requests for re-use of supplemental material or any part of supplemental material shall be sent directly to the copyright owner as specified in the copyright notice associated with the article.

0.00 MB

0.09 MB