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Abstract

Objective

To investigate the biological effects of a novel endovenous scaffold in a porcine model.

Methods

Petalo is a compliant venous scaffold implanted into the internal jugular veins of 12 healthy pigs. The pigs were sacrificed at one, two, three, and six months, respectively. Microscopic investigations were performed at two blinded laboratories.

Results

Neo-intima formation progressively covering up the stent metallic bars was observed. The inflammatory response of the venous wall showed a peak after three months by the implant, followed by marked reduction after six months. The device induced a significant (p < 0.01) increase of the thickness respect to the control regions, but was comparable in sections obtained after three and six months.

Conclusions

The implant of Petalo compliant venous scaffold in the venous wall of this porcine model is characterized by neointima formation and by an inflammatory reaction which tends to decrease after six months. Our data point against the induction of smooth muscle cells proliferation and migration as confirmed by electronic transmission microscopy analyses.

Keywords

Venous stent animal model venous obstruction venous compliance large veins

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A novel endovenous scaffold for the treatment of chronic venous obstruction in a porcine model: Histological and ultrastructural assessment

Abstract

Objective

Methods

Results

Conclusions

Keywords

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References

Supplementary Material