Support perfusion for liver transplantation

Abstract

Addenbrooke's Hospital, Cambridge, UK, has had an ongoing orthotopic liver transplant programme since 1968. Various support bypass techniques have been used intermittently since 1977. In 1990 bypass was needed for 38% of adult liver transplants, and bypass standby was provided for a further 25%. Adult liver recipients (high-risk) are selected for bypass in accordance with a number of surgical and anaesthetic criteria in order to maximize patient benefit and minimize risk. Before the start of the operation two cannulae (8 or 10 Fg) are placed into left and right internal jugular veins and/or the left brachial vein for rapid volume replacement. Femoral and portal vein cannulation (16 to 22 Fg) can quickly be achieved for splanchnic venous drainage to a heparin coated Biomedicus bypass system. This technique provides flows of 1.5 to 2.5 litres per minute with modest perfusion pressures (around 120mmHg) and provides adequate surgical venous decompression and circulatory support during the anhepatic phase.