Pulmonary hypertension and platelet function

Abstract

Platelet number and function were measured in patients (n = 45) who underwent open-heart surgery with cardiopulmonary bypass (CPB). The study showed that platelet adhesion and aggregation were higher in the patients who suffered from congenital heart disease with pulmonary hypertension than in those in the control group, i.e. without pulmonary hypertension. Platelet number and function gradually increased in the experimental group after the operation and postoperative blood loss was greater than that in the control group. The reason for this may have been platelet hyperfunction in patients with pulmonary hypertension, which resulted in platelet destruction and severe depletion during operation. Therefore, it is difficult to achieve haemosttasis and prevent blood loss.

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References

Brecher G. , Cronkite EP Morphology and enumeration of human blood platelets. J Appl Physiol 1950; 3: 365-69.

Salzman EW Measurement of platelet adhesiveness. A simple in vitro technique demonstrating an abnormality in von Willebrand's disease. J Lab Clin Med 1963; 62: 724-35.

Born G. Aggregation of blood platelets by adenosine diphosphate and its reversal. Nature 1962; 194: 927-34.

Ping G. Abnormality of platelet function and hypertension. Fascicle of cardiovascular disease. J Foreign Med 1986; 1: 4-8.

Xi L. Ventricular septal defect with pulmonary hypertension. In: The text book of cardiovascular surgery Beijing: People's Medical Publishing House, 1985.

Girod DA , Hurwitz RA , King H. et al. Recent results of two-stage surgical treatment of large ventricular septal defect. Circulation 1974; 50 (suppl): 9-13.

Hua G. , Heng S. The change in thromboxane and prostacyclin and the effects of persantine on it during cardiopulmonary bypass. Chinese J Thorac Cardiovasc Surg 1986; 2: 174-78.

Lock JE Use of prostacyclin in persistent foetal circulation. Lancet 1979; i: 1343-48.

Ding H. , Li H. Effects of high dose ascorbic acid on haemostasis during and after cardiopulmonary bypass. Perfusion 1988; 3: 281-86.

10.

Suzuki Y. , Ishizawo E. , Tanaka S. Surgical treatment of large ventricular septical defect with pulmonary hypertension in first 24 months of life. Ann Thorac Surg 1976; 22: 228-34.

11.

Ritter DG Long-term follow-up of operated patients with ventricular septal defect and pulmonary hypertension. In: Davila JC ed, Second Henry Ford Hospital International Symposium on Cardiac Surgery, Appleton-Century Crofts, 1977: 234-49.