The renal clearance of β2 microglobulin was measured in two groups of patients undergoing surgery involving cardiopulmonary bypass. The first group of patients received pulsatile perfusion whilst group two were subjected to non pulsatile flow.
There was no difference between the two groups in the rate of β2 clearance throughout the study period. For both groups the clearance rate was signifi cantly elevated from four hours following surgery to the third postoperative day. These results suggest that during standard periods of cardiopulmonary bypass, pulsatile perfusion does not confer any significant advantage over conventional nonpulsatile flow with regard to renal blood flow and tubular function.
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