We describe our experience of 30 consecutive children supported with ECMO and receiving 20 ppm of nitric oxide in the oxygenator of the ECMO circuit. Administration of nitric oxide into the ECMO circuit is safe and could potentially mitigate ischaemia reperfusion injury and end-organ dysfunction of children requiring mechanical support.
SkrzypchakAMLafayetteNGBartlettRHet al. Effect of varying nitric oxide release to prevent platelet consumption and preserve platelet function in an in vivo model of extracorporeal circulation. Perfusion2007; 22: 193–200.
2.
KidaKShirozuKYuBMandevilleJBBlochKDIchinoseF.Beneficial effects of nitric oxide on outcomes after cardiac arrest and cardiopulmonary resuscitation in hypothermia treated mice. Anaesthesiology2014; 120: 880–889.
3.
HeuschG.Molecular basis of cardioprotection: signal transduction in ischemic pre-, post-, and remote conditioning. Circ Res2015; 116: 674–699.
4.
JamesCMillarJHortonSBrizardCMolesworthCButtW.Nitric oxide administration during paediatric cardiopulmonary bypass: a randomised controlled trial. Intensive Care Med2016; 42: 1744–1752.
