Ischaemic preconditioning is one of several different techniques that have been proposed to render the heart more resistant to ischaemia/reperfusion injuries. A significant reduction of troponin release is ‘proof of concept’, however, whether ischaemic preconditioning leads to improved clinical outcomes is still to be proven. Moreover, the exact mechanism of action still remains unknown since very few studies have investigated the signal transmission in humans.
ReimerKAMurryCEYamasawaIHillMLJenningsRB. Four brief periods of myocardial ischaemia cause no cumulative ATP loss or necrosis. Am J Physiol1986; 251: H1306–1315.
2.
SchmidtMRSmerupMKonstantinovIE. Intermittent peripheral tissue ischaemia during coronary ischaemia reduces myocardial infarction through a KATP-dependent mechanism: first demonstration of remote ischaemic perconditioning. Am J Physiol-Heart C2007; 292: H1883–1890.
3.
ZhaoZQCorveraJSHalkosME. Inhibition of myocardial injury by ischaemic postconditioning during reperfusion: comparison with ischaemic preconditioning. Am J Physiol-Heart C2003; 285: H579–588.
4.
JonesWKFanGCLiaoS. Peripheral nociception associated with surgical incision elicits remote nonischaemic cardioprotection via neurogenic activation of protein kinase c signaling. Circulation2009; 120: S1–9.
5.
YellonDMAlkhulaifiAMPugsleyWB. Preconditioning the human myocardium. Lancet1993; 342: 276–277.
6.
NaHSKimYIYoonYWHanHCNahmSHHongSK. Ventricular premature beat-driven intermittent restoration of coronary blood flow reduces the incidence of reperfusion-induced ventricular fibrillation in a cat model of regional ischaemia. Am Heart J1996; 132: 78–83.
7.
OkamotoFAllenBSBuckbergGDBugyiHLeafJ. Reperfusion conditions: importance of ensuring gentle versus sudden reperfusion during relief of coronary occlusion. J Thorac Cardiovasc Surg1986; 92: 613–620.
8.
KerendiFKinHHalkosME. Remote postconditioning. Brief renal ischaemia and reperfusion applied before coronary artery reperfusion reduces myocardial infarct size via endogenous activation of adenosine receptors. Basic Res Cardiol2005; 100: 404–412.
9.
StaatPRioufolGPiotC. Postconditioning the human heart. Circulation2005; 112: 2143–2148.
10.
HeuschGMusiolikJGedikNSkyschallyA. Mitochondrial stat3 activation and cardioprotection by ischaemic postconditioning in pigs with regional myocardial ischaemia/reperfusion. Circ Res2011; 109: 1302–1308.
11.
HeuschG. Cardioprotection: chances and challenges of its translation to the clinic. Lancet2013; c381: c166–175.
12.
RiessMLCamaraAKKevinLGAnJStoweDF. Reduced reactive O2 species formation and preserved mitochondrial nadh and [Ca2+] levels during short-term 17 degrees ischaemia in intact hearts. Cardiovasc Res2004; 61: 580–590.
13.
StoweDFVaradarajanSGAnJSmartSC. Reduced cytosolic Ca(2+) loading and improved cardiac function after cardioplegic cold storage of guinea pig isolated hearts. Circulation2000; 102: 1172–1177.
14.
KhaliulinIClarkeSJLinHParkerJSuleimanMSHalestrapAP. Temperature preconditioning of isolated rat hearts–a potent cardioprotective mechanism involving a reduction in oxidative stress and inhibition of the mitochondrial permeability transition pore. J Physiol2007; 581: 1147–1161.
15.
YellonDMDowneyJM. Preconditioning the myocardium: from cellular physiology to clinical cardiology. Physiol Rev2003; 83: 1113–1151.
16.
DomenechRJSanchezGDonosoPParraVMachoP. Effect of tachycardia on myocardial sarcoplasmic reticulum and Ca2+ dynamics: a mechanism for preconditioning?J Mol Cell Cardiol2003; 35: 1429–1437.
17.
GrossGJHsuAGrossERFalckJRNithipatikomK. Factors mediating remote preconditioning of trauma in the rat heart: central role of the cytochrome p450 epoxygenase pathway in mediating infarct size reduction. J Cardiovasc Pharmacol Therap2013; 18: 38–45.
GhoBCSchoemakerRGvan den DoelMADunckerDJVerdouwPD. Myocardial protection by brief ischaemia in noncardiac tissue. Circulation1996; 94: 2193–2200.
20.
JenkinsDPPugsleyWBAlkhulaifiAMKempMHooperJYellonDM. Ischaemic preconditioning reduces troponin t release in patients undergoing coronary artery bypass surgery. Heart1997; 77: 314–318.
21.
BirnbaumYHaleSLKlonerRA. Ischaemic preconditioning at a distance: reduction of myocardial infarct size by partial reduction of blood supply combined with rapid stimulation of the gastrocnemius muscle in the rabbit. Circulation1997; 96: 1641–1646.
22.
CheungMMKharbandaRKKonstantinovIE. Randomized controlled trial of the effects of remote ischaemic preconditioning on children undergoing cardiac surgery: first clinical application in humans. J Am Coll Cardiol2006; 47: 2277–2282.
23.
HausenloyDJMwamurePKVenugopalV. Effect of remote ischaemic preconditioning on myocardial injury in patients undergoing coronary artery bypass graft surgery: a randomised controlled trial. Lancet2007; 370: 575–579.
24.
ThielmannMKottenbergEKleinbongardP. Cardioprotective and prognostic effects of remote ischaemic preconditioning in patients undergoing coronary artery bypass surgery: a single-centre randomised, double-blind, controlled trial. Lancet2013; 382: 597–604.
25.
LiLLuoWHuangL. Remote perconditioning reduces myocardial injury in adult valve replacement: a randomized controlled trial. J Surg Res2010; 164: e21–26.
26.
WuQGuiPWuJ. Effect of limb ischaemic preconditioning on myocardial injury in patients undergoing mitral valve replacement surgery: a randomized controlled trial. Circulation Journal : Official Journal of the Japanese Circulation Society2011; 75: 1885–1889.
27.
MeybohmPZacharowskiKCremerJ. Remote ischaemic preconditioning for heart surgery. The study design for a multi-center randomized double-blinded controlled clinical trial: the ripheart-study. Eur Heart J2012; 33: 1423–1426.
28.
HausenloyDJCandilioLLaingC. Effect of remote ischaemic preconditioning on clinical outcomes in patients undergoing coronary artery bypass graft surgery (ERICCA): rationale and study design of a multi-centre randomized double-blinded controlled clinical trial. Clinical Research in Cardiology : Official Journal of the German Cardiac Society. 2012; 101: 339–348.
29.
SlagsvoldKHJohnsenABRognmoOHoydalMAWisloffUWahbaA. Mitochondrial respiration and microRNA expression in right and left atrium of patients with atrial fibrillation. Physiol Genomics2014; 46:505–511.
30.
HeuschGMusiolikJKottenbergEPetersJJakobHThielmannM. Stat5 activation and cardioprotection by remote ischaemic preconditioning in humans: Short communication. Circulation research. 2012; 110: 111–115.
31.
Haji Mohd YasinNAHerbisonPSaxenaPPraporskiSKonstantinovIE. The role of remote ischaemic preconditioning in organ protection after cardiac surgery: a meta-analysis. J Surg Res2014; 186: 207–216.
32.
YangLWangGDuYJiBZhengZ. Remote ischaemic preconditioning reduces cardiac troponin I release in cardiac surgery: a meta-analysis. J Cardiothorac Vasc Anesth2014; 28: 682–689.
33.
ZhouCLiuYYaoY. Beta-blockers and volatile anesthetics may attenuate cardioprotection by remote preconditioning in adult cardiac surgery: a meta-analysis of 15 randomized trials. J Cardiothorac Vasc Anesth2013; 27: 305–311.
34.
PilcherJMYoungPWeatherallMRahmanIBonserRSBeasleyRW. A systematic review and meta-analysis of the cardioprotective effects of remote ischaemic preconditioning in open cardiac surgery. J Royal Soc Med2012; 105: 436–445.
35.
D’AscenzoFCavalleroEMorettiC. Remote ischaemic preconditioning in coronary artery bypass surgery: a meta-analysis. Heart2012; 98: 1267–1271.
36.
YetginTManintveldOCBoersmaE. Remote ischaemic conditioning in percutaneous coronary intervention and coronary artery bypass grafting. Circulation Journal: Official Journal of the Japanese Circulation Society. 2012; 76: 2392–2404.
37.
BrevoordDKrankePKuijpersMWeberNHollmannMPreckelB. Remote ischaemic conditioning to protect against ischaemia-reperfusion injury: a systematic review and meta-analysis. PLos One2012; 7: e42179.
38.
AlrejaGBuganoDLotfiA. Effect of remote ischaemic preconditioning on myocardial and renal injury: meta-analysis of randomized controlled trials. J Inv Cardiol2012; 24: 42–48.
39.
TakagiHUmemotoT. Remote ischaemic preconditioning for cardiovascular surgery: an updated meta-analysis of randomized trials. Vasc Endovasc Surg2011; 45: 511–513.
40.
TakagiHManabeHKawaiNGotoSNUmemotoT. Review and meta-analysis of randomized controlled clinical trials of remote ischaemic preconditioning in cardiovascular surgery. Am J Cardiol2008; 102: 1487–1488.
41.
Abdul-GhaniSHeesomKJAngeliniGDSuleimanMS. Cardiac phosphoproteomics during remote ischaemic preconditioning: a role for the sarcomeric z-disk proteins. BioMed Res Int2014; 2014: 767812.
42.
ZografosTAKatritsisGDTsiafoutisIBourboulisNKatsivasAKatritsisDG. Effect of one-cycle remote ischaemic preconditioning to reduce myocardial injury during percutaneous coronary intervention. Am J Cardiol2014; 113: 2013–2017.
43.
SabbaghSHenry SalzmanMMKlonerRASimkhovichBZRezkallaSH. Remote ischaemic preconditioning for coronary artery bypass graft operations. Ann Thorac Surg2013; 96: 727–736.
44.
The Remote Preconditioning TrialistsHealyDAKhanWAWongCS. Remote preconditioning and major clinical complications following adult cardiovascular surgery: systematic review and meta-analysis. Int J Cardiol2014; 176: 20–31.
