The aim of this study was to evaluate the oxidant-antioxidant balance in patients with abdominal aortic aneurysms (AAA). Forty-two consecutive patients with AAA and 46 control subjects were included. Total oxidant status (TOS) and total antioxidant status (TAS) levels were measured and the oxidative stress index (OSI) value determined. Serum TOS and OSI values in patients with AAA were higher than those in the controls (p<0.001, p<0.001, respectively). There was a positive correlation between abdominal aortic diameters, serum TOS levels (r=0.592, p<0.001) and OSI values (r=0.598, p<0.001). A cut-off value of 17.68 µmol H2O2 equivalent/L for TOS was associated with 86% sensitivity and 83% specificity and a cut-off value of 1.77 for OSI was associated with 86% sensitivity and 81% specificity for predicting AAA. Systemic oxidative imbalance develops in patients with AAA, particularly as a result of an increase in TOS.
DiehmNDickFSchaffnerT. Novel insight into the pathobiology of abdominal aortic aneurysm and potential future treatment concepts. Prog Cardiovasc Dis2007; 50: 209–217.
2.
Martinez-PinnaRLindholtJSBlanco-ColioLM. Increased levels of thioredoxin in patients with abdominal aortic aneurysms (AAAs). A potential link of oxidative stress with AAA evolution. Atherosclerosis2010; 212: 333–338.
3.
PalmieriDPaneBBarisioneC. Resveratrol counteracts systemic and local inflammation involved in early abdominal aortic aneurysm development. J Surg Res2011; 171: 237–246.
4.
Martinez-PinnaRRamos-MozoPMadrigal-MatuteJ. Identification of peroxiredoxin-1 as a novel biomarker of abdominal aortic aneurysm. Arterioscler Thromb Vasc Biol2011; 31: 935–943.
5.
CafueriGParodiFPistorioA. Endothelial and smooth muscle cells from abdominal aortic aneurysm have increased oxidative stress and telomere attrition. PLoS One2012; 7: 35312.
6.
SangiorgiGD’AverioRMaurielloA. Plasma levels of metalloproteinases-3 and -9 as markers of successful abdominal aortic aneurysm exclusion after endovascular graft treatment. Circulation2001; 104 :288–295.
7.
KanekoHAnzaiTMorisawaM. Resveratrol prevents the development of abdominal aortic aneurysm through attenuation of inflammation, oxidative stress, and neovascularization. Atherosclerosis2011; 217: 350–357.
8.
MorimotoKHasegawaTTanakaA. Free-radical scavenger edaravone inhibits both formation and development of abdominal aortic aneurysm in rats. J Vasc Surg2012; 55: 1749–1758.
9.
MillerFJJrSharpWJFangX. Oxidative stress in human abdominal aortic aneurysms: a potential mediator of aneurysmal remodeling. Arterioscler Thromb Vasc Biol2002; 22: 560–565.
10.
McCormickMLGavrilaDWeintraubNL. Role of oxidative stress in the pathogenesis of abdominal aortic aneurysms. Arterioscler Thromb Vasc Biol2007; 27: 461–469.
11.
SzaszTThakaliKFinkGD. A comparison of arteries and veins in oxidative stress: producers, destroyers, function, and disease. Exp Biol Med2007; 232: 27–37.
12.
ErelO. A new automated colorimetric method for measuring total oxidant status. Clin Biochem2005; 38: 1103–1111.
13.
RabusMDemirbağRSezenY. Plasma and tissue oxidative stress index in patients with rheumatic and degenerative heart valve disease. Turk Kardiyol Dern Ars2008; 36: 536–540.
14.
YazıcıSDemirtasSGucluO. Using oxidant and antioxidant levels to predict the duration of both acute peripheral and mesenteric ischemia. Perfusion2014; 29: 450–455.
15.
MenteseUDoganOVTuranI. Oxidant-antioxidant balance during on-pump coronary artery bypass grafting. Scientific World Journal. 2014; 2014: 263058. doi: 10.1155/2014/263058.
16.
TuranTMenteşeUAğaçMT. The relation between intensity and complexity of coronary artery lesion and oxidative stress in patients with acute coronary syndrome. Anadolu Kardiyol Derg2015; 15: 795-800.
17.
ErelO. A novel automated method to measure total antioxidant response against potent free radical reactions. Clin Biochem2004; 37: 112–119.
18.
KoksalCErcanMBozkurtAK. Abdominal aortic aneurysm or aortic occlusive disease: role of trace element imbalance. Angiology2007; 58: 191–195.
19.
PapalambrosESigalaFGeorgopoulosS. Malondialdehyde as an indicator of oxidative stress during abdominal aortic aneurysm repair. Angiology2007; 58: 477–482.
20.
Ramos-MozoPMadrigal-MatuteJMartinez-PinnaR. Proteomic analysis of polymorphonuclear neutrophils identifies catalase as a novel biomarker of abdominal aortic aneurysm: potential implication of oxidative stress in abdominal aortic aneurysm progression. Arterioscler Thromb Vasc Biol2011; 31: 3011–3019.
21.
DubickMAHunterGCCaseySM. Aortic ascorbic acid, trace elements, and superoxide dismutase activity in human aneurysmal and occlusive disease. Proc Soc Exp Biol Med1987; 184: 138–143.
22.
DubickMAKeenCLDiSilvestroRA. Antioxidant enzyme activity in human abdominal aortic aneurysmal and occlusive disease. Proc Soc Exp Biol Med1999; 220: 39–45.
23.
SakalihasanNPincemailJDefraigneJO. Decrease of plasma vitamin E (alpha-tocopherol) levels in patients with abdominal aortic aneurysm. Ann NY Acad Sci1996; 800: 278–282.
24.
AslanMCosarNCelikH. Evaluation of oxidative status in patients with hyperthyroidism. Endocrine2011; 40: 285–289.
25.
GuzikBChwalaMMatusikP. Mechanisms of increased vascular superoxide production in human varicose veins. Pol Arch Med Wewn2011; 121: 279–286.
26.
IzzottiACartigliaCLongobardiM. Alterations of gene expression in skin and lung of mice exposed to light and cigarette smoke. FASEB J2004; 18: 1559–1561.
27.
PappEGadawskiICôtéHC. Longitudinal effects of thymidine analogues on mtDNA, mtRNA and multidrug resistance (MDR-1) induction in cultured cells. J Antimicrob Chemother2008; 61: 1048–1052.
28.
DrachJGsurAHamiltonG. Involvement of P-glycoprotein in the transmembrane transport of interleukin-2 (IL-2), IL-4, and interferon-gamma in normal human T lymphocytes. Blood1996; 88: 1747–1754.
29.
ManduzSKatrancıogluNKarahanO. Associations between common 3435 C>T variants of the multi-drug resistance [MDR-1 (ABCB1)] gene and abdominal aortic aneurysm: a pilot study. Turkish J Thorac Cardiovasc Surg2011; 19: 177–181.
30.
Martin-VenturaJLMadrigal-MatuteJMartinez-PinnaR. Erythrocytes, leukocytes and platelets as a source of oxidative stress in chronic vascular diseases: detoxifying mechanisms and potential therapeutic options. Thromb Haemost2012; 108: 435–442.
