Oxygen consumption,carbon dioxide production and lactic acid during normothermic cardiopulmonary bypass

Abstract

The objective of this study was to measure oxygen consumption, carbondioxide production and lactic acid levels during normothermic cardiopulmonary bypass. A prospective study was undertaken in a tertiary care community hospital, involving 20 adults undergoing cardiopulmonary bypass with prolonged (>65 min) crossclamping of the aorta. O₂ consumption, CO₂ production, hemoglobin and lactic acid levels were measured 5, 35 and 65 min after crossclamping of the aorta. O₂ consumption was 79.7 ± 14.5, 78.8 ± 15.4 and 81.5 ± 14.1 ml/min/m² at 5, 35 and 65 min after crossclamping the aorta. CO₂ production was 61.8 ± 42.9, 60.6 ± 26.3 and 62.2 ± 35.9 ml/min/m² at the same times. Lactic acid levels were 1.6 ± 0.5 mM/dl at all three times and did not correlate with O₂ consumption or CO₂ production.

In conclusion, although oxygen consumption was low, there was no evidence of abnormal lactate or anaerobic metabolism to suggest tissue ischemia.