The cytotoxicities to 3T3-L1 cells of 150 coded chemicals, estimated by the FRAME kenacid blue method, are given as a basis for further studies on the relative in vitro toxicities of related and distinct sets of test chemicals, and as a basis for future attempts at the comparison and correlation of estimates of toxicity obtained in vitro and in vivo.
The expression of the results of in vitro cytotoxicity tests is discussed, as are various ways of comparing values obtained for different chemicals. It is suggested that there should be agreement on the inclusion of a standard set of reference chemicals in all cytotoxicity test validation trials.
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