The anniversary of the Fund for the Replacement of Animals in Medical Experiments (FRAME) provides an opportunity to celebrate the Charity's achievements over the past 40 years, and in particular, its contribution to the international acceptance of the Three Rs as the basis of an ethic for animal experimentation, and its role as a leader in the implementation of the Three Rs in the life sciences. The Canadian Council on Animal Care (CCAC) has based its work on the Three Rs, especially since the establishment of its fundamental CCAC Policy Statement on the Ethics of Animal Investigation (1989). Following recommendations from the evaluation of its programmes by external committees established by the national granting agencies, the CCAC recently launched a Three Rs Program. This programme will build on the work of FRAME and other similar Three Rs organisations, to further the promotion and implementation of the Three Rs in Canadian science.
GauthierC. & GriffinG. (2005). Using animals in research, testing and teaching. Revue scientifique et technique (International Office of Epizootics)24, 735–745.
SchuppliC.A. & McDonaldM. (2005). Contrasting modes of governance for the protection of humans and animals in Canada: lessons for reform. Health Law Review13, 97–106.
6.
RussellW.M.S. & BurchR.L. (1959). The Principles of Humane Experimental Technique, 238pp. London, UK: Methuen. [Re-issued: 1992, by Universities Federation for Animal Welfare, Potters Bar, Herts., UK.] Available at: http://altweb.jhsph.edu/publications/humane_exp/het-toc.htm (Accessed 04.09.09).
7.
DemersG., GriffinG., De VroeyG., HaywoodJ.R., ZurloJ. & BedardM. (2006). Harmonization of animal care and use guidance. Science, New York312, 700–701.
8.
BallsM., GoldbergA.M., FentemJ.H., BroadheadC.M., BurchR.L., FestingM.F.W., FrazierJ.M., HendriksenC.F.M., JenningsM., van der KampM.D.O., MortonD.B., RowanA.N., RussellC., RussellW.M.S., SpielmannH., StephensM.L., StokesW.L., StraughanD.W., YagerJ.D., ZurloJ. & van ZutphenB.F.M. (1995). The Three Rs: The Way Forward. The report and recommendations of ECVAM Workshop 11. ATLA23, 838–866.
9.
Howard-JonesN. (1985). A CIOMS ethical code for animal experimentation. World Health Organization Chronicle39(2), 51–56.
10.
GriffinG. & GauthierC. (2004). Incorporation of the Three Rs in wildlife research. ATLA32 Suppl. 1A, 215–219.
11.
SchuppliC.A., FraserD. & McDonaldM. (2004). Expanding the Three Rs to meet new challenges in humane animal experimentation. ATLA32, 525–532.
12.
OrmandyE.H., SchuppliC.A. & WearyD. (2009). Worldwide trends in the use of animals in research: the contribution of genetically-modified animal models. ATLA37, 63–68.
13.
BhogalN. & CombesR. (2006). The relevance of genetically altered mouse models of human disease. ATLA34, 429–454.
14.
FenwickN., GriffinG. & GauthierC. (2009). The welfare of animals used in science: how the “Three Rs” ethic guides improvements. Canadian Veterinary Journal50, 523–530.
15.
SmythD.H. (1978). Alternatives to Animal Experiments, 220pp. London, UK: Scolar Press in association with the Research Defense Society.
16.
GuyA. & GriffinG. (2009). Adopting alternatives for the regulatory monitoring of shellfish for paralytic shellfish poisoning in Canada: interface between federal regulators, science and ethics. Regulatory Toxicology & Pharmacology54, 256–263.
17.
GuyA., GauthierC. & GriffinG. (2008). Adopting alternative methods for regulatory testing in Canada. In Proceedings of the 6th World Congress on Alternatives & Animal Use in the Life Sciences. AATEX14, Special Issue, 322–327.
18.
GauthierC. (2002) Principles and guidelines for the development of a science-based decision making process facilitating the implementation of the 3Rs by governmental regulators. ILAR Journal43, S99–S104.
ComberJ.M. & GriffinG. (2007). Genetic engineering and other factors that might affect humananimal interactions in the research setting. Journal of Applied Animal Welfare Science10, 267–277.
21.
LawrenceJ.F., NiedzwiadekB. & MenardC. (2005). Quantitative determination of paralytic shellfish poisoning toxins in shellfish using prechromatographic oxidation and liquid chromatography with fluorescence detection: collaborative study. Journal of Association of Analytical Communities International88, 1714–1732.
