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Abstract

At the opening of a meeting to celebrate the 50th anniversary of the publication of The Principles of Humane Experimental Technique, by W.M.S. Russell and R.L. Burch, and the 40th anniversary of the establishment of FRAME, some comments on the early days of the Charity are made, with particular reference to the special contributions made by its founder-Chairman, Dorothy Hegarty, and the author's own appointment as a Trustee, and later as Chairman. Reference is made to some key events and successes, and especially to the importance of FRAME's move from London to Nottingham, and the establishment of an ongoing collaboration with the University of Nottingham, including the setting-up of the FRAME Alternatives Laboratory.

Keywords

animal experimentation Dorothy Hegarty FRAME Nottingham University replacement Three Rs

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References

Russell

W.M.S.

& Burch

R.L.

(1959). The Principles of Humane Experimental Technique, 238pp. London, UK: Methuen.

Annett

(1995). The Fund for the Replacement of Animals In Medical Experiments (FRAME): the first 25 years. ATLA 23, 19–32.

Hegarty

(1995). Dorothy Hegarty and the founding of FRAME: a personal recollection. ATLA 23, 15–17.

Balls

(1995). On keeping your eyes on the prize: Dorothy Hegarty and acceptance of the concept of replacement. ATLA 23, 756–774.

Rowan

(2009). FRAME: the early days. ATLA 37, Suppl. 2, 7–12.

Russell

W.M.S.

& Burch

R.L.

(1995). Prefatory note. ATLA 23, 11–13.

Russell

W.M.S.

(1995). The development of the Three Rs concept. ATLA 23, 298–304.

Burch

R.L.

(1995). The progress of humane experimental technique since 1995: a personal view. ATLA 23, 776–783.

Hollands

(1995). Achieving the achievable: animals in politics. ATLA 23, 33–38.

10.

Straughan

D.W.

(1995). The role of the Home Office Inspector. ATLA 23, 39–49.

11.

Festing

(1995). Reduction of animal use in the 35 years after Russell & Burch's Principles of Humane Experimental Technique. ATLA 23, 51–60.

12.

Rowan

& Goldberg

(1995). Responsible animal research: a riff of Rs. ATLA 23, 306–311.

13.

Morton

D.B.

(1995). Advances in refinement in animal experimentation over the past 25 years. ATLA 23, 812–822.

14.

PACE (1995). Poor Model Man: Experimenting on Chimpanzees. ATLA 23, 571–651.

15.

Smyth

(1978). Alternatives to Animal Experiments, 218 pp. London, UK: Scolar Press.

16.

Balls

& Monnickendam

(eds) (1976). Organ Culture in Biomedical Research, 570pp. Cambridge, UK: Cambridge University Press.

17.

Balls

(1977). ‘Alternatives’ to living animals: towards a rational view of current status and future prospects. ATLA Abstracts 5 (1), 10–19.

18.

Balls

& Rao

(1980). Organ culture in pharmacology. In The Use of Alternatives in Drug Research (ed. Rowan

A.N.

& Stratman

C.J.

), pp. 49–69. London, UK: Macmillan.

19.

Balls

(2009). The origins and early days of the Three Rs concept. ATLA 37, 255–265.

20.

Johnston

(2009). Keeping the archives at the University of Nottingham ATLA 37, Suppl. 2, 107–111.

21.

Paskal

(2009). Finding the courage: The unconventional lives of W.M.S. and Claire Russell. ATLA 37, Suppl. 2, 101–106.

22.

Balls

(2009). The Three Rs and the Humanity Criterion, 131pp. Nottingham, UK: FRAME.

23.

Balls

, Firmani

& Rowan

A.N.

(eds) (2004). The Three Rs at the Beginning of the 21st Century. Proceedings of the Fourth World Congress on Alternatives and Animal Use in the Life Sciences, New Orleans, LA, USA (2002). ATLA 32, Suppl. 1, 1–758.

24.

Balls

, van Zeller

A-M.

& Halder

(2000). Progress in the Reduction, Refinement and Replacement of Animal Experimentation, 1795pp. Amsterdam, The Netherlands: Elsevier.

25.

Hothorn

L.A.

, Bretz

, Edler

, Hauschke

, Hothorn

, Ittrich

& Schäfer

(2003). Biostatistical methods and the development, validation and application of in vitro toxicity tests. ATLA 31, Suppl. 1, 1–103.

FRAME,Animal Experimentation and the Three Rs: Past,Present and Future

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