Background: There are no studies that have systematically reviewed the currently available evidence on the influence of vitamin E-supplementation on orthodontic tooth movement (OTM). Aim: The objective of this systematic review is to assess the influence of vitamin E-supplementation on OTM. Methods: Indexed databases were searched without time and language restrictions up to and including October 2025. Original studies addressing the focused question “Does vitamin E-supplementation affect OTM?” were included. Different combinations (Boolean operators) of keywords were used, and independent reviewers screened the studies for eligibility. The Risk of bias (RoB) and quality of studies were assessed using the Systematic Review Centre for Laboratory Animal Experimentation tool and Grading of Recommendations, Assessment, Development, and Evaluation analysis, respectively. Disagreements were resolved via discussion. Summary: Four studies performed on animal models were included. The magnitude of the orthodontic forces administered ranged from 10 g to 50 g. The route and dosage of vitamin E-supplementation varied between studies. One study showed no influence of vitamin E-supplementation on OTM; and three reported that vitamin E-supplementation increases OTM. Three studies reported that vitamin E-supplementation increases osteoblast activity and one reported that vitamin E-supplementation increases osteoclastic activity. Prior sample-size-estimation was performed in none of the studies. All studies had an unclear RoB and a low overall certainty of evidence. Since a limited number of preclinical studies, characterized by a high RoB and a low certainty of evidence fulfilled the eligibility criteria, the influence of vitamin E-supplementation on OTM remains inconclusive. Further well-designed, blinded, and power-adjusted randomized controlled trials with standardized vitamin E-supplementation related parameters are needed.
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