Background:
Breastfeeding is a crucial practice offering significant nutritional and health benefits to infants and mothers. Despite global recommendations, colostrum avoidance remains a prevalent issue in various regions, including Bangladesh. Aim: The objective of this study was to investigate the prevalence of colostrum avoidance among mothers and its associated factors in Noakhali, Bangladesh. Methods: A total of 397 mothers of infants less than six months seeking care at Noakhali General Hospital were included in this cross-sectional study. A face-to-face interview was taken using a structured questionnaire. Results: About 37% of the mothers were observed to practice colostrum avoidance. Employment status was a significant factor, with employed mothers having 5.422 higher odds of colostrum avoidance than unemployed mothers (p < 0.001). Additionally, mothers having > 1 child were less likely to avoid colostrum (adjusted odds ratio: 0.412, 95% confidence interval: 0.188–0.901, p = 0.026). Conclusion: Colostrum avoidance was evident among a high proportion of mothers. Hence, the findings recommend more targeted interventions to promote colostrum feeding, address cultural beliefs, and enhance quality breastfeeding counseling during antenatal and postnatal care.