A 68-year-old man underwent a left upper lobectomy for squamous cell lung carcinoma. After 15 days, he was readmitted with fever, dyspnea, and a skin rash. Computed tomography showed a pleural effusion, which was drained. He was diagnosed with hemophagocytic syndrome in view of the fever, skin rash, bicytopenia, hypertriglyceridemia, high lactate dehydrogenase, and raised ferritin levels. His clinical condition deteriorated in spite of steroid therapy, and he died on the 23rd postoperative day.
FismanDN. Hemophagocytic syndromes and infection. Emerg Infect Dis2000; 6: 601–608.
2.
HenterJIHorneAAricóMEgelerRMFilipovichAHImashukuS. HLH-2004: diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer2007; 48: 124–131.
3.
AkamatsuNSugawaraYTamuraSMatsuiYHasegawaKImamuraH. Hemophagocytic syndrome after adult-to-adult living donor liver transplantation. Transplant Proc2006; 38: 1425–1428.
4.
OtoTSnellGIGotoKMiyoshiS. Hemophagocytic syndrome: a rare but specific complication of lung transplantation. J Thorac Cardiovasc Surg2010; 140: e58–e59.
5.
YamadaTIkeyaTOgawaTNakanoMOguraHItohH. A hemophagocytic syndrome-like condition after emergency colectomy for perforated colon cancer: report of a case. Surg Today2002; 32: 278–281.
6.
KoduriPRCarandangGDeMaraisPPatelAR. Hyperferritinemia in reactive hemophagocytic syndrome report of four adult cases. Am J Hematol1995; 49: 247–249.
7.
MorrellDSPeppingMAScottJPEsterlyNBDroletBA. Cutaneous manifestations of hemophagocytic lymphohistiocytosis. Arch Dermatol2002; 138: 1208–1212.
8.
HenterJIElinderGOstA. Diagnostic guidelines for hemophagocytic lymphohistiocytosis. The FHL Study Group of the Histiocyte Society. Semin Oncol1991; 18: 29–33.
9.
StroutMPSeropianSBerlinerN. Alemtuzumab as a bridge to allogeneic SCT in atypical hemophagocytic lymphohistiocytosis. Nat Rev Clin Oncol2010; 7: 415–420.
