The relationship of eustachian tube surfactant and otitis media with effusion on eustachian tube opening pressure was studied in a gerbil model. Injection of killed Streptococcus pneumoniae bacteria created a serous effusion that increased eustachian tube opening pressure. The introduction of exogenous surfactant to this system resulted in a dramatic decrease in eustachian tube opening pressure in both normal ears and those with effusion. Identifying means to increase surfactant in the eustachian tube could be beneficial in reducing persistent otitis media with effusion.
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References
1.
PaperellaM.Pathogenesis of middle ear effusions. Ann Otol Rhinol Laryngol1976;85 (Suppl):259–62.
2.
DanielsF.AlbertyR.Physical chemistry, ed 4. New York: John Wiley & Sons, 1975: 252.
3.
VonNeergardK.Neue Auffassugen über einen Grundbegriff der Atemmechanik. Die Retraktionskraft der Lunge. Abhangig von der Oberflächenspannung in der Alveolen. Z Ged Exptl Med1929; 66: 373.
4.
MavesM.PatilGSLimD.Surface-active substance of the guinea pig tubotympanum. A chemical and physical analysis. OTOLARYNGOL HEAD NECK SURG1981; 89: 307–16.
5.
FlisbergK.IngelstedtS.OrtegreuU.The valve and “locking” mechanism of the eustachian tube. Acta Otolaryngol Suppl (Stockh)1963;182:57–68.
6.
BirkenEABrooklerKH. Surface lowering substance of the canine eustachian tube. Laryngoscope1977;81:268–71.
7.
MalmL.WhiteP.Isoprenaline-induced facilitation of the eustachian tube opening. Acta Otolaryngol (Stockh)1984; 98:391–7.
8.
HaganWE. Surface tension lowering substance in eustachian tube function. Laryngoscope1977;87:1033–45.
9.
WhiteP.Effect of exogenous surfactant on eustachian tube function in the rat. Am J Otolaryngol1989;10:301–4.
10.
DanielHJMeansLWDresselMEKoeschePJ. Otitis media in laboratory rats. Physiol Psychol1973;1:7–8.
11.
DanielHJFulghumRSBrinnJEBarrettMS. Comparative anatomy of eustachian tube and middle ear cavity models for otitis media. Ann Otol Rhinol Laryngol1982;91:82–9.
12.
LowellSHJuhnSKGiebinkGS. Experimental otitis media following middle ear inoculation of nonviable Streptococcus pneumoniae. Ann Otol Rhinol Laryngol1980;89:479–82.
13.
BirkenEABrooklerKH. Surface tension lowering substance in non-suppurative otitis media: an experiment with dogs. Laryngoscope1972;81:268–71.
