Although anaphylactic reactions resulting from immunotherapy rarely occur, when they do occur they can be life-threatening. The literature reveals more than 30 deaths attributed to immunotherapy but numerous reports of anaphylaxis. We reviewed a 5-year experience of immunotherapy in a University practice and their experience with systemic reactions is presented. More than 125,000 injections were given in this time period. Of the 550 patients receiving immunotherapy, 14% experienced anaphylactic reactions, the majority of which were mild.
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References
1.
LockeyRFBenedictLMTurkeltaubPCBukantzSC. Fatalities from immunotherapy and skin testing. J Allergy Clin Immunol1987; 79: 660–77
2.
Van ArsdelPPShermanWB. The risk of inducing constitutional reactions in allergic patients. J Allergy1957; 28: 251–61
3.
CookeRA. Studies in specific hypersensitivity: III. On constitutional reactions: the dangers of the diagnostic cutaneous test and therapeutic injection of allergens. J Immunol1922; 7: 119–46
4.
VervloetDKhairallahEArnaudACharpinV.A prospective national study of the safety of immunotherapy. Clin Allergy1980; 10: 59
5.
RansonJH. Frequency of reactions to alum-precipitated ragweed extract. Ann Allergy1971; 29: 635
6.
KaufmanCRSummersRJRenardRL. Safety of immunotherapy: a prospective study. Ann Allergy1984; 52: 220
FigleyKD. The continuous method of hayfever treatment. J Allergy1931; 2: 39
9.
FurstonbergFFGayLN. The occurrence of constitutional reactions in the treatment of hayfever and asthma: analysis of corrective factors. Bull Johns Hopkins1937; 60: 412
10.
GreenbergMAKaufmanCRGonzalezGERosenblattCDSmithLJSummersRJ. Late and immediate systemic-allergic reactions to inhalant allergen immunotherapy. J Allergy Clin Immunol1986; 77: 865–70
IliopoulosOProudDAdkinsonNFJrEffects of immunotherapy on the early, late, and rechallenge nasal reaction to provocation with allergen: changes in inflammatory mediators and cells. J Allergy Clin Immunol1991; 87: 855–66
13.
FurinMJNormanPSCreticosPSImmunotherapy decreases antigen-induced eosinophil cell migration into the nasal cavity. J Allergy Clin Immunol1991; 88: 1
14.
GordonBR. Allergy skin tests and immunotherapy: comparison of methods in common use. Ear Nose Throat J1990; 69: 47–61
