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Abstract

This study investigated the role of hypervitaminosis A on the developing larynx. Pregnant rats received a dose of 100,000 units of Vitamin A on either Day 8 or Day 11 of gestation. The hyaline laryngeal cartilages of the neonatal rats were studied. The cricoid and arytenoid cartilages appeared to be the most affected. There was a pronounced central disorganization of the structure of the cartilage, with numerous swollen lacunae devoid of chondrocytes. The thyroid cartilage was the least affected. The center of the cartilage displayed a minimal amount of disorganization, when compared to the control. The effect of hypervitaminosis A on cartilaginous tissue is discussed, as well as its possiible effect on the development of laryngeal cartilages.

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The Histologic Effect of Hypervitaminosis A on Laryngeal Cartilages

Abstract

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