A synthetic prostaglandin E2 analog was compared in the dog to xylometazoline hydrochloride and natural PGE1 and PGE2 for nasal decongestant activity. Using both in vivo nasal patency tests and in vitro nasal blood vessel contraction tests, the synthetic analog was more effective, was very long-acting, and did not change blood pressure at effective systemic or topical doses.
Get full access to this article
View all access options for this article.
References
1.
. StovallRJacksonRT: Prostaglandins and nasal blood flow. Ann Otol Rhinol Laryngol1967; 76: 1051–1059.
2.
. JacksonRT: Prostaglandin E1 as a nasal constrictor in normal human volunteers. Curr Ther Res1970; 12: 711–717.
3.
. AnggardA: The effect of prostaglandins on nasal airway resistance in man. Ann Otol Rhinol Laryngol1969; 78: 657–662.
4.
. KarimSMMAdaikanPGKunaratnamN: Effect of topical prostaglandins on nasal patency in man. Prostaglandins1978; 15: 457–462.
5.
. KarimSMMAdaikanPGKunaratnamN: Effect of 17-phenyl PGF2a on nasal patency in man. Prostaglandins Med1979; 3: 33–37.
6.
. JacksonRT: A new in vitro method of drug assay of nasal blood vessels. Arch Otorhinolaryngol1979; 225: 33–38.
7.
. JacksonRT: An in vitro technique for testing nasal vaso-dilating agents. Otolaryngol Head Neck Surg1980; 88: 434–438.
8.
. LipptonHLChapnickBMKadowitzPJ: Influence of prostaglandins on vasoconstrictor responses in the hindquarters vascular bed of the cat. Prostaglandins Med1981; 6: 183–202.
9.
. HedqvistP: Basic methods of prostaglandin action on autonomic transmission. Annu Rev Pharmacol Toxicol1977; 17: 259–279.
10.
. HatanoYKohliJDGoldbergLI: Relative contracting and relaxing potencies of a series of prostaglandins on isolated canine mesenteric artery strips. Prostaglandins1981; 21: 515–529.
