Twenty-one cases of mucoepidermoid-adenosquamous carcinoma (MEC/ASC) of the larynx and hypopharynx were collected and reviewed from the Armed Forces Institute of Pathology tumor registry from 1945 to 1979. This is the largest series of such lesions in this location reported to date. In addition, the literature was reviewed and 32 previous cases noted. The overall five-year survival was 77%, although low-grade mucoepidermoid carcinoma had a better survival than did adenosquamous—high-grade mucoepidermoid carcinoma.
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References
1.
VolkmannI: Uber endothelial Geschwulste zugleich ein Beitrag zu den Speicheldrusen und Gaumentumoren. Dtsch Z Chir41: 1, 1895.
2.
StewartFWFooteFWBeckerWF: Mucoepidermoid tumors of salivary glands. Ann Surg122: 820–844, 1945.
3.
FooteFWJrFrazellEL: Tumors of the major salivary glands. Cancer6: 1065–1133, 1953.
4.
BhaskarSNBernierJL: Mucoepidermoid tumors of major and minor salivary glands. Cancer15: 801–817, 1962.
EversoleLRRovinSSabesWR: Mucoepidermoid carcinoma of minor salivary glands: Report of 17 cases with follow-up. J Oral Surg30: 107–112, 1972.
7.
FineGMarshallRBHorneRC: Tumors of the minor salivary glands. Cancer13: 653, 1960.
8.
ThorvaldssonSEBeahrsOHWoolnerLB: Mucoepidermoid tumors of the major salivary glands. Am J Surg120: 432–438, 1970.
9.
SpiroRHKossLGHajduSI: Tumors of minor salivary origin: A clinicopathologic study of 492 cases. Cancer31: 117–129, 1973.
10.
SpiroRHLewisJSHajduSI: Mucus gland tumors of the larynx and laryngopharynx. Ann Otol Rhinol Laryngol85: 498–503, 1976.
11.
SpiroRHHuvasAG: Mucoepidermoid carcinoma of salivary gland origin: A clinicopathologic study of 367 cases. Am J Surg136: 461–468, 1978.
12.
GerughtyRMHennigarGRBrownFM: Adenosquamous carcinoma of the nasal, oral and laryngeal cavities. Cancer22: 1140–1155, 1968.
13.
American Joint Committee for Cancer Staging and End-results Reporting: Manual for Staging of Cancer 1978. Chicago, Whiting Press, 1978, pp 16–44.
14.
FooteFWJrFrazellEL: Tumors of the major salivary glands. Atlas of tumor pathology, Armed Forces Institute of Pathology, 1954, Section 4, Fasc 11.
15.
TomitaTOtuacoL: Mucoepidermoid carcinoma of the subglottis: An ultrastructural study. Arch Pathol Lab Med101: 145–148, 1977.
16.
BossartA: Zur Kenntnis einer ungewohnlichen epithelialen Kiefergeschwulst (hypernephroides adamantinom). Schweiz Monatschr Zahnh55: 91–104, 1945.
17.
ThomasK: Mucoepidermoid carcinoma of the larynx. J Laryngol Otol85: 261–267, 1971.
18.
HamperlHHellwegG: On mucoepidermoid tumors of various sites. Cancer10: 1187–1192, 1957.
19.
EvansRW: Histological Appearance of Tumors With Consideration of Their Histogenesis and Certain Aspects of Their Clinical Features and Behavior. Edinburgh and London, E & S Livingstone Ltd, 1956.
20.
SeoISTomichCEWarfelKA: Clear cell carcinoma of the larynx-A variant of mucoepidermoid carcinoma. Ann Otol Rhinol Laryngol89: 168–172, 1980.
21.
ReynoldsCTMcAuleyRLRogersWP: Experience with tumors of minor salivary glands. Am J Surg111: 168–174, 1960.
22.
FrableWJElzayRP: Tumors of minor salivary glands. Cancer25: 932–941, 1973.
23.
SessionsDGMurrayJPBauerWC: Adenocarcinoma of the larynx. Can J Otol4: 293–296, 1975.
24.
CadyBRippeyJHFrazellEL: Nonepidermoid cancer of the larynx. Ann Surg167: 116–120, 1968.
25.
MurattiG: Epitelioma muco-epidermoide della larynge. Arch Ital Otol80: 131–153, 1969.
DavisWEBeckMR: Mucoepidermoid carcinoma of the larynx: A case report. Ear Nose Throat Monthly54: 394–396, 1975.
28.
FerlitoA: Histological classification of larynx and hypopharynx cancers and their clinical implications. Pathologic aspects of 2052 malignant neoplasms diagnosed at the ORL Dept of Padua University from 1966 to 1976. Acta Otolaryngol (suppl 342), 1976.
29.
KaznelsonDJSchindelJ: Mucoepidermoid carcinoma of the air passages: Report of three cases. Laryngoscope89: 115–121, 1979.
30.
GattiWErkman-BalisB: Mucoepidermoid carcinoma of the larynx. Arch Otolaryngol106: 52–53, 1980.
31.
WhickerWNeelB: Adenocarcinoma of larynx. Ann Otol Rhinol Laryngol83: 487–490, 1974.
32.
NewGBErichJB: Adenocarcinoma of the larynx. Ann Otol Rhinol Laryngol50: 706–714, 1941.
33.
HavensFParkhillE: Tumors of the larynx other than squamous cell epithelioma. Arch Otolaryngol34: 1113–1122, 1941.
34.
BinderWJSomPKanekoM: Mucoepidermoid carcinoma of the larynx—A case report and review of the literature. Ann Otol Rhinol Laryngol89: 103–107, 1980.
