The clinical histories of three patients with neurogenous sarcomas involving the head and neck are detailed. The most satisfactory treatment suggested for such tumors involves combined therapy with chemotherapy, radiation, and radical surgical excision. By so doing, potential patient cure might be further increased and survival rates further improved.
Get full access to this article
View all access options for this article.
References
1.
BatsakisJG: Tumors of the Head and Neck. Baltimore, Williams & Wilkins Co, 1974, pp 235–249.
2.
ConleyJJ: Neurogenous tumors in the neck. Arch Otolaryngol61: 167–180, 1955.
3.
D'AgostinoANSouleEHMillerRH: Primary malignant neoplasm of nerves (malignant neurilemomas) in patients without manifestation of multiple neurofibromatosis (Von Recklinghausen's disease). Cancer16: 1003–1014, 1963.
4.
HarkinJCReedRJ: Tumors of the Peripheral Nervous System. Atlas of Tumor Pathology, Armed Forces Institute of Pathology, 1969, section 3, pp 107–125.
5.
AlviraMMMandybarTIMenefeeMG: Light microscopic and ultrastructural observations of metastasizing malignant epithelioid schwannoma. Cancer38: 1977–1982, 1976.
6.
GhoshBCGhoshLHuvosAG: Malignant schwannnoma: A clinicopathologic study. Cancer35: 184–190, 1973.
VietaJOPackGT: Malignant neurilemmomas of peripheral nerves. Am J Surg82: 416–431, 1951.
9.
Das GuptaTKBrasfieldRD: Solitary malignant schwannoma. Ann Surg171: 419–448, 1970.
10.
WhiteHR: Survival in malignant schwannoma: An 18 year study. Cancer27: 720–729, 1971.
11.
D'AgostinoANSouleEHMillerRH: Sarcomas of the peripheral nerves and somatic soft tissue associated with multiple neurofibromatosis (Von Recklinghausen's disease). Cancer16: 1015–1027, 1963.
12.
ValdesOSMaurerHM: Combination therapy with vincristine sulfate and cyclophosphamide for generalized malignant schwannoma: A case report. Cancer Chemother Rep54: 65–68, 1970.
13.
KraghLVSouleEHMassonJK: Benign and malignant neurilemonas of the head and neck. Surg Gynecol Obstet3: 211–218, 1950.
14.
SuitHDRussellWO: Radiation therapy of soft tissue sarcomas. Cancer36: 759–764, 1975.
15.
OmuraGARobertsGA: Combination therapy of solid tumor using 1, 3-Bis (2 chloroethyl)-1-nitrosourea (BCNU), vincristine, methotrexate and 5 fluorouracil. Cancer31: 1374–1381, 1973.
16.
WilburJRSutowWWSullivanMP: Chemotherapy of sarcomas. Cancer36: 765–769, 1975.
17.
GottliebJABakerLHO'BryanRM: Adriamycin (NSC-123127) used alone and in combination for soft tissue and bony sarcomas. Cancer Chemother Rep6: 271–282, 1975.
18.
GoldmanRLJonesSEHeusinkueldRS: Combination chemotherapy of metastatic malignant schwannoma with vincristine, adriamycin cyclophosphamide, and imidazole carboximide. Cancer39: 1955–1958, 1977.
