We sought to describe the patient, tumor, and survival characteristics of minor salivary gland carcinoma (MSGC) of the oropharynx using a large, population-based database.
Study Design
Cross-sectional analysis of the National Cancer Institute’s SEER database (Surveillance, Epidemiology. and End Results).
Subjects and Methods
We reviewed the SEER database for all cases of MSGC of the oropharynx from 1988 to 2013. Relevant demographic, clinicopathologic, and survival variables were extracted and analyzed. Cox multivariate regression was performed to identify prognostic factors.
Results
We identified 1426 cases of MSGC of the oropharynx (mean age, 58 years; 51% female). The soft palate (39.2%) and base of tongue (38.6%) were the most commonly involved sites. The most common histologic subtypes were mucoepidermoid carcinoma (32.1%), adenocarcinoma (25.9%), and adenoid cystic carcinoma (23.3%). Five- and 10-year rates of disease-specific survival were 75.1% and 61.6%, respectively. Independent prognostic factors included tumor grade, T stage, N stage, and age >70 years.
Conclusions
This study represents the largest multivariate survival analysis of MSGC of the oropharynx to date. Independent prognosticators include tumor grade, T stage, N stage, and age.
OrdRAPazokiAE. Salivary gland disease and tumors. In: MiloroMGhaliGCLarsenPEWaitePD eds. Peterson’s Principles of Oral and Maxillofacial Surgery. 2nd ed.Hamilton, Canada: BC Decker Inc; 2004:671-677.
2.
EvesonJWCawsonRA. Tumours of the minor (oropharyngeal) salivary glands: a demographic study of 336 cases. J Oral Pathol. 1985;14:500-509.
3.
SpiroRH. Salivary neoplasms: overview of a 35-year experience with 2,807 patients. Head Neck. 1986;8:177-184.
4.
StrickMJKellyCSoamesJVMcLeanNR. Malignant tumours of the minor salivary glands: a 20 year review. Br J Plast Surg. 2004;57:624-631.
5.
SpiroRHKossLGHajduSIStrongEW. Tumors of minor salivary origin: a clinicopathologic study of 492 cases. Cancer. 1973;31:117-129.
6.
BurbankPMDockertyMBDevineKD. A clinicopathologic study of 43 cases of glandular tumors of the tongue. Surg Gynec Obst. 1959;109:573-582.
7.
BaddourHMFedewaSAChenAY. Five- and 10-year cause-specific survival rates in carcinoma of the minor salivary gland. JAMA Otolaryngol Head Neck Surg. 2016;142:67-73.
8.
SpiroRHSpiroJD. Cancer of the salivary glands. In: MyersENSuenJY eds. Cancer of the Head and Neck. New York, NY: Churchill Livingstone; 1989:645-668.
9.
BardwilJMReynoldsCTIbanezMLLunaMA. Report of one hundred tumors of the minor salivary glands. Am J Surg. 1966;112:493-497.
10.
de VriesEJJohnsonJTMyersENBarnesELJrMandell-BrownM. Base of tongue salivary gland tumors. Head Neck Surg. 1987;9:329-331.
11.
RoperPRWolfPFLunaMAGoepfertH. Malignant salivary gland tumors of the base of the tongue. South Med J. 1987;80:605-608.
12.
KesslerDJMickelRACalcaterraTC. Malignant salivary gland tumors of the base of the tongue. Arch Otolaryngol. 1985;111:664-666.
13.
GoepfertHGiraldoAAByersRMLunaMA. Salivary gland tumors of the base of the tongue. Arch Otolaryngol. 1976;102:391-395.
14.
ChijiwaHSakamotoKUmenoHNakashimaTSuzukiGHayafuchiN. Minor salivary gland carcinomas of oral cavity and oropharynx. J Laryngol Otol. 2009;123:52-57.
15.
HosokawaYShiratoHKageiKet al. Role of radiotherapy for mucoepidermoid carcinoma of salivary gland. Oral Oncol. 1999;35:105-111.
16.
GregorRTHengBB. Minor salivary gland carcinomas of the mouth and oropharynx. J Otolaryngol. 1981;10:267-272.
17.
IyerNGKimLNixonIJet al. Factors predicting outcome in malignant minor salivary gland tumors of the oropharynx. Arch Otolaryngol Head Neck Surg. 2010;136:1240-1247.
18.
HandARPathmanathanDFieldRB. Morphological features of the minor salivary glands. Arch Oral Biol. 1999;44(suppl 1):S3-S10.
19.
VillanuevaNLDe almeidaJRSikoraAGMilesBAGendenEM. Transoral robotic surgery for the management of oropharyngeal minor salivary gland tumors. Head Neck. 2014;36:28-33.
20.
CarrilloJFMaldonadoFCarrilloLCet al. Prognostic factors in patients with minor salivary gland carcinoma of the oral cavity and oropharynx. Head Neck. 2011;33:1406-1412.
21.
RöösliCTschudiDCStuderGBraunJStoeckliSJ. Outcome of patients after treatment for a squamous cell carcinoma of the oropharynx. Laryngoscope. 2009;119:534-540.
22.
Bastos de souzaTRPintoCAda Cunha MercanteAMNishimotoINBrasilino de CarvalhoMKowalskiLP. Long-term results of surgical treatment for advanced oropharyngeal squamous cell carcinoma. Head Neck. 2014;36:1146-1154.
23.
HyamDMVenessMJMorganGJ. Minor salivary gland carcinoma involving the oral cavity or oropharynx. Aust Dent J. 2004;49:16-19.
24.
WaldronCAel MoftySKGneppDR. Tumors of the intraoral minor salivary glands: a demographic and histologic study of 426 cases. Oral Surg Oral Med Oral Pathol. 1988;66:323-333.
25.
van der WalJESnowGBvan der WaalI. Histological reclassification of 101 intraoral salivary gland tumors (new WHO classification). J Clin Pathol. 1992;45:834-835.
26.
Vander PoortenVLMBalmAJMHilgersFJMTanIBKeusRBHartAAM. Stage as major long term outcome predictor in minor salivary gland carcinoma. Cancer. 2000;89:1195-1204.
27.
SpiroRHThalerHTHicksWFKherUAHuvosAHStrongEW. The importance of clinical staging of minor salivary gland carcinoma. Am J Surg. 1991;162:330-336.
28.
ParsonsJTMendenhallWMStringerSPCassisiNJMillionRR. Management of minor salivary gland carcinomas. Int J Radiat Oncol Biol Phys. 1996;35:443-454.
29.
JonesASBeasleyNJHoughtonDJHelliwellTRHusbandDJ. Tumours of the minor salivary glands. Clin Otolaryngol Allied Sci. 1998;23:27-33.
30.
AndersonJNJrBeenkenSWCroweRet al. Prognostic factors in minor salivary gland cancer. Head Neck. 1995;17:480-486.
31.
LeivoI. Insights into a complex group of neoplastic disease: advances in histopathologic classification and molecular pathology of salivary gland cancer. Acta Oncol. 2006;45:662-668.
32.
SpiroRHHuvosAG. Stage means more than grade in adenoid cystic carcinoma. Am J Surg. 1992;164:623-628.
33.
Vander PoortenVHuntJBradleyPJet al. Recent trends in the management of minor salivary gland carcinoma. Head Neck. 2014;36:444-455.
34.
KakaralaKBhattacharyyaN. Survival in oral cavity minor salivary gland carcinoma. Otolaryngol Head Neck Surg. 2010;143:122-126.
35.
GoldblattLIEllisGL. Salivary gland tumors of the tongue. Cancer. 1987;60:74-81.
36.
NasriSOhYCalcaterraTC. Transpharyngeal approach to base of tongue tumors: a comparative study. Laryngoscope. 1996;106:945-950.
37.
JenkinsDWSpauldingCAConstableWCCantrellRW. Minor salivary gland tumors: the role of radiotherapy. Am J Otolaryngol. 1989;10:250-256.
38.
SadeghiATranLMMarkRSidrysJParkerRG. Minor salivary gland tumors of the head and neck: treatment strategies and prognosis. Am J Clin Oncol. 1993;16:3-8.
39.
GardenASWeberRSAngKKMorrisonWHMatreJPetersLJ. Postoperative radiation therapy for malignant tumors of minor salivary glands: outcome and patterns of failure. Cancer. 1994;73:2563-2569.
40.
LeQTBirdwellSTerrisDJet al. Postoperative irradiation of minor salivary gland malignancies of the head and neck. Radiother Oncol. 1999;52:165-171.
41.
EiseleDWKleinbergLRO’MalleyBB. Management of malignant salivary gland tumors. In: HarrisonLBSessionsRBHongKH eds. Head and Neck Cancer: A Multidisciplinary Approach. Philadelphia, PA: Lippincott-Raven; 1999:721-748.
