Abstract
Objective: There are studies about the hypertrophy of the base of the tongue due to gastroesophageal reflux (GER), but there have been no reports explaining the effects of GER on the base of the tongue histopathologically. Therefore, we investigated the histopathologic changes of tongue base using an experimental model of reflux.
Method: The randomized study was conducted at Haydarpasa Numune Hospital. Eighteen rats were divided into 3 groups according to exposure time, and 4 rats were examined as controls. An experimental model of gastroesophageal reflux was induced. The histopathological changes in the base of the tongue were observed under a light microscope.
Results: At the end of the first week, only subepithelial edema was significantly different in the exposed group when compared to the control group. After 4 weeks in addition to subepithelial edema, submucosal gland hypertrophy was significantly different from the control group. When we assessed submucosal gland hypertrophy and subepithelial edema in the group exposed to refluxate for 12 weeks, they were found to be much increased compared with the 4-week group. Also, inflamation, vascular dilatation, and achantosis were determined to be significantly increased compared with the control group.
Conclusion: The current study suggests that GER results in histopathological changes in the base of the tongue. Therefore, it suggests a new perspective to the relationship between GER and throat clearing, dry cough, and especially globus pharyngeus.
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