Long-term Follow-up of Laryngeal Amyloidosis

Abstract

Objective: 1) Laryngeal amyloidosis is a rare disease and most of the knowledge is from single case reports. In this paper, we aim to present one of the larger series of primary laryngeal amyloidosis reported in the English written literature. 2) To understand the disease course and be able to describe long term outcomes in these patients.

Method: Retrospective review of six patients with laryngeal amyloidosis followed at a tertiary university voice center. The patient charts were reviewed for initial presentation, workup, and surgeries or other treatments performed. Serial laryngoscopic examinations were reviewed. Voice handicap index was used to evaluate voice outcomes.

Results: Majority of the patients required multiple surgeries to control the disease. Endoscopic approach with CO₂ laser excision was the preferred technique. Attention was given to preserve the function of the larynx. During follow-up, patients who had an adequate vocal quality preferred observation only with no further surgeries or treatment. Long-term follow-up shows an indolent course of the disease.

Conclusion: The extended follow-up allows us to provide recommendations on treatment options and surgical technique. Since this is a slowly progressing disease, the main objective should be to preserve laryngeal function as long as possible.