Abstract
Objective: The real impact of virus infection in the perpetuation of chronic rhinosinusitis (CRSsNP) and nasal polyps (CRSwNP) is still to be established. The purpose of this study was to evaluate the prevalence of rhinovirus RNA in nasal lavage from patients with CRSwNP and CRSsNP, without acute exacerbations.
Method: Nasal and sinusal (maxillary) lavages were collected from a total of 36 patients with CRSwNP and CRSsNP, during ESS procedure, from July 2008 to August 2010. The RNA of human rhinovirus was evaluated through RT-qPCR using TaqMan primers specific to human rhinovirus sp.
Results: Rhinovirus RNAs were found in 19 (51.35%) of the samples. Correlation between nasal and sinusal lavages was of 61%. There was no correlation between rhinovirus prevalence and seasonality. Rhinovirus was present in 6 out of 13 samples of CRSsNP (46%) and 12 out of 23 samples of CRSwNP (52%). Lund Mackay score ranged from 2 to 8 (mean 4.4) among CRSsNP patients and from 8 to 24 (mean 14) among CRSwNP patients. Mean Lund-Mackay score was similar between patients with or without rhinovirus, both for CRSwNP (16.9 vs 17.3, respectively) and CRSsNP (5.4 vs 3.5, respectively).
Conclusion: There is a very high prevalence of rhinovirus RNA in nasal lavages from patients with CRSsNP and CRSwNP.
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