Abstract
Objective: Acetylcysteine (AC) is an antioxidant agent with mucolytic effect and reported to enhance mucosal immunity. Our hypothesis was that adding AC to currently used drugs in patients with subacute sinusitis increases improvement and prevents further complications, such as progression to chronic sinusitis.
Method: Forty-five patients with subacute sinusitis were enrolled in trial. All received Amoxicillin-Clavulanic acid, Pseudoephedrine, and saline drop. In addition patients received AC in the intervention group but placebo in control group. Symptoms and CT findings were assessed at baseline and 45 days after by Snot 20 questionnaire and Lund-Mackay score.
Results: No significant improvement was seen in the clinical and radiological findings by adding oral AC to Amoxicillin-Clavulanic acid, Pseudoephedrine, and nasal saline drop, comparing Snot 20 and Lund-Mackay score after treatment between groups.
Conclusion: Adding oral Acetylcysteine to currently used drugs in the treatment of subacute sinusitis has no significant benefit.
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