Polymorphous Low-Grade Adenocarcinoma

Abstract

Objective: We present a series of 18 cases of polymorphous low-grade adenocarcinoma.

Method: We retrospectively reviewed all documented cases of polymorphous low-grade adenocarcinoma at our institution since 1984. Each case was confirmed by pathologic examination.

Results: The median age of this series is 59 years. Eleven out of the 18 patients were female and 13 were white. Fifteen of the tumors were located on the hard/soft palate. Nearly every patient was treated with wide local excision, and 8 required reconstruction with flaps. Only 3 patients were treated with postoperative radiation. 4 patients were treated for recurrences, 2 of which were originally treated 20 years prior.

Conclusion: Polymorphous low-grade adenocarcinoma is a rare and slow growing entity. Surgical excision is the treatment of choice and radiation therapy is generally not needed. Long term follow-up is required, as recurrences have been noted after long periods of time. Differentiation from adenoid cystic carcinoma can be difficult.