Abstract
Program Description: The incidence of Human Papilloma Virus (HPV)–related oropharyngeal cancer is increasing at a near-epidemic proportion. As such, otolaryngologists are diagnosing and treating greater numbers of patients, especially younger patients, with this distinct disease. There have been significant strides in our knowledge about the pathophysiology of this disease. Yet despite our increased knowledge, there are still several unanswered questions about the ideal management. The educational objective of this miniseminar is to provide otolaryngologists with up-to-date clinically relevant information about making treatment decisions for patients with oropharyngeal cancer. This will be done using a case-based format in the style of a multidisciplinary tumor board with incorporating audience participation. The cases discussed will incorporate basic concepts and controversial topics within the discussion. These topics will include 1) initial management with surgical techniques versus non-surgical modalities, 2) incorporating biomarkers (HPV, p16, others) and patient-related factors into initial treatment decision making, 3) optimal management of the neck, 4) management of patients with persistent/recurrent primary site disease after completion of initial therapy, and 5) management of patients with an unknown primary site when the neck metastasis is HPV positive. Panel members will provide support for their responses based on the best evidence-based medicine available. Standard available therapies, currently available and upcoming clinical trials, and future research directions will be emphasized. At the conclusion of this miniseminar, the participant will be able to describe the current “state-of-the-art” for evaluation and management of oropharynx cancer and discuss the underlying principles for how treatment decisions are made.
Educational Objectives: 1) Describe the current “state-of-the-art” for evaluation and management of HPV-associated oropharynx cancer. 2) Discuss the underlying principles for making treatment decisions for patients with oropharynx cancer. 3) Describe current standard treatment options, available clinical trials, and future research directions.
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