Platform Presentations

De Bondt HL , Rosenblatt J. , Jancarik J. , Jones HD , Morgan DO , and Kim S.-H. (1993). Crystal structure of cyclin-dependent kinase 2 . Nature (London) 363: 595-602.

Desai D. , Gu Y. , and Morgan DO (1992). Activation of human cyclin-dependent kinases in vitro. Mol. BioL Cell 3: 571-582.

Gu Y. , Rosenblatt J. , and Morgan DO (1992). Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15. EMBO J. 11: 3995-4005.

Koff A. , Ohtsubo M. , Giordano A. , Desai D. , Yamashita K. , Harper JW , Elledge S. , Nishimoto T. , Morgan DO , Franza R. , and Roberts JM (1992). G1 regulation by human cyclin E and a cyclin E/CDK2 complex. Science 257: 1689-1694.

Rosenblatt J. , Gu Y. , and Morgan DO (1992). Human cyclin-dependent kinase 2 (CDK2) is activated during the S and G2 phases of the cell cycle and associates with cyclin A. Proc. Natl. Acad. Sci. USA 89: 2824-2828.

Allsopp RC , Vaziri H. , Patterson C. , Goldstein S. , Younglai EV , Futcher AB , Greider CW , and Harley CB (1992). Telomere length predicts replicative capacity of human fibroblasts. Proc. Natl. Acad. Sci. USA 89: 10114-10118.

Collins K. and Greider CW (1993). Tetrahymena telomerase catalyzes nucleolytic cleavage and nonprocessive elongation. Genes Dev. 7: 1364-1376.

Counter CM , Avilion AA , LeFeuvre CE , Stewart NG , Greider CW , Harley CB , and Bacchetti S. (1992). Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity . EMBO J. 11: 1921-1929.

Greider CW and Blackburn EH (1989). Nature (London) 337: 331-337.

Harley CB , Futcher AB , and Greider CW (1990). Telomeres shorten during ageing of human fibroblasts . Nature (London) 345: 458-460.

Harrington LA and Greider CW (1991). Telomerase primer specificity and chromosome healing. Nature (London) 353: 451-454.

Hastie ND , Dempster M. , Dunlop MG , Thompson AM , Green DK , and Allshire RC (1990). Telomere reduction in human colorectal carcinoma and with ageing (commen). Nature (London) 346: 866-868.

Prowse KR , Avilion AA , and Greider CW (1993). Identification of a nonprocessive telomerase activity from mouse cells. Proc. Natl. Acad. Sci. USA 90:1493-1497.

Yu G-L. , Bradley JD , Attardi LD , and Blackburn EH (1990). Nature (London) 344: 126-132.

Doll R. and Peto R. (1981). The causes of cancer in the United States today . JNCI 66: 1192-1308.

Hartwell LH and Weinert TA (1989). Checkpoints: Controls that ensure the order of cell cycle events. Science 246: 629-634.

Hollstein M. , Sidransky D. , Vogelstein B. , and Harris CC (1991). p53 mutations in human cancers. Science 253:49-53.

Kastan MB , Onyekwere O. , Sidransky D. , Vogelstein B. , and Craig RW (1991). Participation of p53 in the cellular response to DNA damage. Cancer Res. 51: 6304-6311.

Kastan MB , Zhan Q. , El-Deiry WS , Carrier F. , Jacks T. , Walsh WV , Plunkett BS , Vogelstein B. , and Fornace AJ Jr. (1992). A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell 71: 587-597.

Kuerbitz SJ , Plunkett BS , Walsh WV , and Kastan MB (1992). Wild-type p53 is a cell cycle checkpoint determinant following irradiation. Proc. Natl. Acad. Sci. USA 89: 7491-7495.

Weinert TA and Hartwell LH (1988). The RAD9 gene controls the cell cycle response to DNA damage in Saccharomyces cerevisiae. Science 241: 317-322.

Compton DA , Szilak I. , and Cleveland DW (1991). Primary structure of NuMA, an intranuclear protein that defines a novel pathway for segregation of proteins at mitosis. J. Cell Biol. 116: 1395-1408.

Tousson A. , Zeng C. , Brinkley BR , and Valdivia MM (1991). Centrophilin: A novel mitotic spindle protein involved in microtubule nucleation. J. Cell Biol. 112: 427-447.

Yang CH , Lambie EJ , and Snyder M. (1991). NuMA: An unusually long coiled-coil related protein in the mammalian nucleus. J. Cell Biol. 116: 1303-1317.

Livingstone LR , White A. , Sprouse J. , Livanos E. , Jacks T. , and Tlsty TD (1992). Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53. Cell 70: 923-935.

Otto E. , McCord S. , and Tlsty TD (1989). Increased incidence of CAD gene amplification in tumorigenic rat lines as an indicator of genomic instability of neoplastic cells. J. Biol. Chem. 264: 3390-3396.

Tlsty TD (1990). Normal diploid human and rodent cells lack a detectable frequency of gene amplification. Proc. Natl. Acad. Sci. USA 87: 3132-3136.

Tlsty TD , Margolin B. , and Lum K. (1989). Differences in the rates of gene amplification in nontumorigenic and tumorigenic cell lines as measured by Luria-Delbruck fluctuation analysis. Proc. Natl. Acad. Sci. USA 86:9441-9445.

Tlsty TD , White A. , and Sanchez J. (1992). Suppression of gene amplification in human cell hybrids. Science 255: 1425-1437.

Bartek J. , Bartkova J. , Vojtesek B. , Staskova Z. , Rejthar A. , Kovarik J. , and Lane DP (1990). Patterns of expression of the p53 tumour suppressor in human breast tissues and tumours in situ and in vitro. Int. J. Cancer 46: 839-844.

Bennett WP , Hollstein MC , Metcalf RA , Welsh JA , He A. , Zhu S. , Kusters I. , Resau JH , Trump BF , Lane DP , and Harris CC (1992). p53 mutation and protein accumulation during multistage human esophageal carcinogenesis. Cancer Res. 52: 6092-6097.

Brash DE , Rudolph JA , Simon JA , Lin A. , McKenna GJ , Baden HP , Halperin AJ , and Ponten J. (1991). A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma. Proc. Natl. Acad. Sci. USA 88: 10124-10128.

Bressac B. , Kew M. , Wands J. , and Ozturk M. (1991). Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa. Nature (London) 350: 429-431.

Caselmann WH , Meyer M. , Kekulë AS , Lauer U. , Hofschneider PH , and Koshy R. (1990). A trans-activator function is generated by integration of hepatitis B virus preS/S sequences in human hepatocellular carcinoma DNA. Proc. Natl. Acad. Sci. USA 87: 2970-2974.

DavidoffAM, Humphrey PA , Iglehart JD , and Marks JR (1991). Genetic basis for p53 overexpression in human breast cancer. Proc. Natl. Acad. Sci. USA 88: 5006-5010.

Harris CC (1991). Chemical and physical carcinogenesis : Advances and perspectives. Cancer Res. 51: 5023s-5044s.

Hino O. , Nomura K. , Ohtake K. , Kawaguchi T. , Sugano H. , and Kitagawa T. (1989). Instability of integrated hepatitis B virus DNA with inverted repeat structure in a transgenic mouse. Cancer Genet. Cytogenet. 37: 273-278.

Hino O. , Tabata S. , and Hotta Y. (1991). Evidence for increased in vitro recombination with insertion of human hepatitis B virus DNA. Proc. Natl. Acad. Sci. USA 88: 9248-9252.

Hollstein M. , Sidransky D. , Vogelstein B. , and Harris CC (1991). p53 mutations in human cancers. Science 253: 49-53.

Hsu IC , Metcalf RA , Sun T. , Welsh J. , Wang NJ , and Harris CC (1991). p53 gene mutational hotspot in human hepatocellular carcinomas from Qidong, China. Nature (London) 350: 427-428.

Kekulë AS , Lauer U. , Meyer M. , Caselmann WH , Hofschneider PH , and Koshy R. (1990). The preS2/S region of integrated hepatitis B virus DNA encodes a transcriptional transactivator. Nature (London) 343: 457-461.

Li D. , Cao Y. , He L. , Wang NJ , and Gu J. (1993). Aberrations of p53 gene in human hepatocellular carcinoma from China. Carcinogenesis 14: 169-173.

Maguire HF , Hoeffler JP , and Siddiqui A. (1991). HBV X protein alters the DNA binding specificity of CREB and ATF-2 by protein-protein interactions. Science 252: 842-844.

Nuorva K. , Soini Y. , Kamel D. , Autio-Harmainen H. , Risteli L. , Risteli J. , Vahakangas K. , and Paakko P. (1993). Concurrent p53 expression in bronchial dysplasias and squamous cell lung carcinomas. Am. J. Pathol. 142: 725-732.

Scorsone KA , Zhou YZ , Butel JS , and Slagle BL (1992). p53 mutations cluster at codon 249 in hepatitis B virus-positive hepatocellular carcinomas from China. Cancer Res. 52: 1635-1638.

Shields PG , and Harris CC (1991). Molecular epidemiology and the genetics of environmental cancer. JAMA 266: 681-687.

Shirakata Y. , Kawada M. , Fujiki Y. , Sano H. , Oda M. , Yaginuma K. , Kobayashi M. , and Koike K. (1989). The X gene of hepatitis B virus induced growth stimulation and tumorigenic transformation of mouse NIH3T3 cells. Jpn. J. Cancer Res. 80: 617-621.

Sozzi G. , Miozzo M. , Donghi R. , Pilotti S. , Cariani CT , Pastorino U. , Della Porta G. , and Pierotti MA (1992). Deletions of 17p and p53 mutations in preneoplastic lesions of the lung. Cancer Res. 52: 6079-6082.

Spandau DF and Lee CH (1988). Trans-activation of viral enhancers by the hepatitis B virus X protein. J. Virol. 62: 427-434.

Sundaresan V. , Ganly P. , Hasleton P. , Rudd R. , Sinha G. , Bleehen NM , and Rabbitts P. (1992). p53 and chromosome 3 abnormalities, characteristic of malignant lung tumours, are detectable in preinvasive lesions of the bronchus. Oncogene 7: 1989-1997.

Twu JS and Schloemer RH (1987). Transcriptional trans-activating function of hepatitis B virus. J. Virol. 61: 3448-3453.

Vahakangas KH , Samet JM , Metcalf RA , Welsh JA , Bennett WP , Lane DP , and Harris CC (1992). Mutations of p53 and ras genes in radon-associated lung cancer from uranium miners. Lancet 339: 576-580.

Barker D. , Schafer M. , and White R. (1984). Restriction sites containing CpG show a higher frequency of polymorphism in human DNA. Cell 36: 131-138.

Brown TC and Jiricny J. (1987). A specific mismatch repair event protects mammalian cells from loss of 5-methylcytosine. Cell 50: 945-950.

Cooper DN and Youssoufian H. (1988). The CpG dinucleotide and human genetic disease . Human Genet. 78:151-155.

Coulondre C. , Miller JH , Farabaugh PJ , and Gilbert W. (1978). Molecular basis of base substitution hotspots in Escherichia coli. Nature (London) 274: 775-780.

Hollstein M. , Sidransky D. , Vogelstein B. , and Harris CC (1991). p53 mutations in human cancers. Science 253: 49-53.

Jones PA , Buckley JD , Henderson BE , Ross RK , and Pike MC (1991). From gene to carcinogen: A rapidly evolving field in molecular epidemiology. Cancer Res. 51: 3617-3620.

Rideout WM III , Coetzee GA , Olumi AF , and Jones PA (1990). 5-Methylcytosine as an endogenous mutagen in the human LDL receptor and p53 genes. Science 249: 1288-1290.

Shen J-C. , Rideout WM III , and Jones PA (1992). High frequency mutagenesis by a DNA methyltransferase . Cell 71: 1073-1080.

Sved J. and Bird A. (1990). The expected equilibrium of the CpG dinucleotide in vertebrate genomes under a mutational model. Proc. Natl. Acad. Sci. USA 87: 4692-4696.

Borish ET , Cosgrove JP , Church DF , Deutsch WA , and Pryor WA (1986). Cigarette smoke, free radicals, and biological damage. In: Superoxide and Superoxide Dismutase in Chemistry, Biology, and Medicine, G Rotilio (ed). Elsevier, Amsterdam, pp. 467-472.

Borish ET , Cosgrove JP , Church DF , Deutsch WA , and Pryor WA (1985). Cigarette tar causes single-strand breaks in DNA. Biochem. Biophys. Res. Commun. 133: 780-786.

Borish ET , Pryor WA , Venugopal S. , and Deutsch WA (1987). DNA synthesis is blocked by cigarette tar-induced DNA single-strand breaks. Carcinogenesis 8: 1517-1520.

Church DF and Pryor WA (1985). Free-radical chemistry of cigarette smoke and its toxicological implications. Environ. Health Perspect. 64: 111-126.

Church DF and Pryor WA (1991). The oxidative stress placed on the lung by cigarette smoke. In: The Lung, Vol. 2, RG Crystal , JB West , PJ Barres , NS Cherniack , and ER Weibel (eds). Raven Press, New York, pp. 1975-1979.

Cosgrove JP , Borish ET , Church DF , and Pryor WA (1985). The metal-mediated formation of hydroxyl radical by aqueous extracts of cigarette tar. Biochem. Biophys. Res. Commun. 132: 390-396.

Evans MD , Church DF , and Pryor WA (1991). Aqueous cigarette tar extracts damage human alpha-1-proteinase inhibitor. Chem. Biol. Interact. 79: 151-164.

Halliwell B. , Borish ET , Pryor WA , et al (1987). Oxygen radicals and human disease. Ann. Intern. Med. 107: 526-545.

Moreno JJ , Foroozesh M. , Church DF , and Pryor WA (1992). Release of iron from ferritin by aqueous extracts of cigarette smoke. Chem. Res. Toxicol. 5: 116-123.

Moreno JJ and Pryor WA (1992). Inactivation of α-1-proteinase inhibitor by peroxynitrite. Chem. Res. Toxicol. 5: 425-431.

Nakayama T. , Church DF , and Pryor WA (1989). Quantitative analysis of the hydrogen peroxide formed in aqueous cigarette tar extracts. Free Rad. Biol. Med. 7: 9-15.

Pryor WA (1987). Cigarette smoke and the involvement of free radical reactions in chemical carcinogenesis. Br. J. Cancer 55(suppl. VIII): 19-23.

Pryor WA (1987). The free radical chemistry of cigarette smoke and the inactivation of alpha-1-proteinase inhibitor. In: Pulmonary Emphysema and Proteolysis: 1986, JC Taylor and C Mittman (eds). Academic Press, Orlando, FL, pp. 369-392.

Pryor WA (1987). The free-radical theory of aging revisited: A critique and a suggested disease-specific theory. In: Modern Biological Theories of Aging, HR Warner , RN Butler , and RL Sprott (eds). Raven Press, New York, pp. 89-112.

Pryor WA , Arbour NC , Upham B. , and Church DF (1992). The inhibitory effect of extracts of cigarette tar on electron transport of mitochondria and sub-mitochondrial particles . Free Rad. Biol. Med. 12: 365-372.

Pryor WA , Dooley MM , and Church DF (1986). The inactivation of α-1-proteinase inhibitor by gas-phase cigarette smoke: Protection by antioxidants and reducing species . Chem. Biol. Interact. 57: 271-283.

Pryor WA , Dooley MM , and Church DF (1984). Inactivation of human alpha-1-proteinase inhibitor by gas-phase cigarette smoke. Biochem. Biophys. Res. Commun . 122: 676-681.

Pryor WA , Dooley MM , and Church DF (1985). Mechanisms of cigarette smoke toxicity: The inactivation of human alpha-1-proteinase inhibitor by nitric oxide/isoprene mixtures in air. Chem. Biol. Interact. 54: 171-183.

Pryor WA , Dooley MM , and Church DF (1986). The mechanisms of the inactivation of human alpha-1-proteinase inhibitor by gas-phase cigarette smoke. Adv. Free Rad. Biol. Med. 2: 161-188.

Pryor WA , Prier DG , and Church DF (1983). Electron-spin resonance study of mainstream and sidestream cigarette smoke: Nature of the free radicals in gas-phase smoke and in cigarette tar. Environ. Health Perspect. 47: 345-355.

Pryor WA and Stone K. (1993). Oxidants in cigarette smoke; radicals, hydrogen peroxide, peroxynitrate, and peroxynitrite. In: Tobacco Smoking and Nutrition: Influence of Nutrition on Tobacco Associated Health Risks, J Diana and WA Pryor (eds). New York Academy of Sciences, New York, pp. 12-28.

Pryor WA , Tamura M. , and Church DF (1984). ESR spin trapping study of the radicals produced in NOx/ olefin reactions: A mechanism for the production of the apparently long-lived radicals in gas-phase cigarette smoke. J. Am. Chem. Soc. 106: 5073-5079.

Glick AB , Kulkarni AB , Tennenbaum T. , Hennings H. , Flanders KC , O'Reilly M. , Sporn MB , Karlsson S. , and Yuspa SH (1993). Loss of transforming growth factor beta expression in skin and skin tumors is associated with hyperproliferation and a high risk for malignant conversion. Proc. Natl. Acad. Sci. USA 90: 6076-6088.

Glick AB and Yuspa SH (in press). The participation offos and jun in multistage carcinogenesis . In: Cellular and Viralfos Genes, P Herrlick and P Angel (eds). CRC Press, Boca Raton, FL.

Hennings H. , Glick AB , Lowry DT , Krsmanovic LS , Sly LM , and Yuspa SH (in press). FVB/N mice: An inbred strain sensitive to the chemical induction of squamous cell carcinomas in the skin. Carcinogenesis .

Tennenbaum T. , Yuspa SH , Grover A. , Castronovo V. , Sobel ME , Yamada Y. , and De Luca LM (1992). Extracellular matrix receptors and mouse skin carcinogenesis : Altered expression linked to appearance of early markers of tumor progression. Cancer Res. 52: 2966-2976.

Cavenee WK (1992). Accumulation of genetic defects during astrocytoma progression. Cancer 70:1788-1793.

Lasko D. , Cavenee WK , and Nordenskjöld M. (1991). Loss of constitutional heterozygosity in human cancer. Ann. Rev. Genet. 25: 281-314.

Sidransky D. , Mikkelsen T. , Schwechheimer K. , Rosenblum ML , Cavenee WK , and Vogelstein B. (1992). Clonal expansion of p53 mutant cells leads to brain tumor progression . Nature (London) 355: 846-847.