The incidence of invasive spontaneous pituitary carcinomas in Fischer-344 rats were studied. The pituitaries were examined histopathologically together with surrounding tissues including sphenoid bone. The incidence of carcinoma was higher than that previously reported in Fischer-344 rats. All the carcinomas observed in this study showed evidence of local invasion either ventrally into bone and bone marrow or laterally into peripheral nerves and blood vessels. No dorsal infiltration into the brain was recognized. Pituitary carcinoma with local invasion is a relatively common neoplasm when examined histopathologically together with the surrounding tissues.
1. Berkvens JM, Van Nesselrooij JH, and Kroes R (1980). Spontaneous tumors in the pituitary gland of old Wistar rats. A morphologic and immunocytochemical study. J. Pathol130: 179–191.
2.
2. Burek JD (1978). Tumors of the anterior pituitary gland. In: Pathology of Aging RatsCRC Press, West Palm Beach, FL, pp. 49–53.
3.
3. Carlton WW and Gries CL (1983). Adenoma and carcinoma, pars distalis, rat. In: Monographs on Pathology of Laboratory Animals. Endocrine System, TC J ones, U Mohr, and RD Hunt (eds). International Life Sciences Institute, Springer-Verlag, Berlin pp 134–145.
4.
4. Furth J, Nakane P, and Pasteels JL (1976). Tumors of the pituitary gland. In: Pathology of Tumors in Laboratory Animals, Vol. 1, Tumors of the Rat, part 2, VS Turusov (ed). International Agency for Research on Cancer Scientific Publications, Lyon, pp. 201–227.
5.
5. Greaves P and Faccini JM (1984). Endocrine glands. In: Rat HistopathologyElsevier, Amsterdam, pp. 187–201.
6.
6. Haseman JK, Huff J, and Boorman GA (1984). Use of historical control data in carcinogenicity studies in rodents. Toxicol. Pathol12: 126–135.
7.
7. Iwata H, Hirouchi Y, Koike Y, Yamakawa S, Kobayashi K, Yamamoto T, Kobayashi K, Inoue H, and Enomoto M (1991). Historical control data of nonneoplastic and neoplastic lesions in F-344/Ducrj rats. J. Toxicol. Pathol4: 1–24.
8.
8. Mackenzie WF and Boorman GA (1990). Pituitary gland. In: Pathology of the Fischer Rat. Reference and Atlas, GA Boorman, SL Eustis, MR Elwell, CA Montgomery, and WF MacKenzie (eds). Academic Press, San Diego, pp. 485–500.
9.
9. MacKenzie WF and Garner FM (1973). Comparison of neoplasms in six source of rats. JNCI50: 1243–1257.
10.
10. Maekawa A, Kurokawa Y, Takahashi M, Kokubo T, Ogiu T, Onodera H, Tanigawa H, Ohno Y, Furukawa F, and Hayashi Y (1983). Spontaneous tumors in F-344/Ducrj rats. Gann74: 365–372.
11.
11. Maita K, Hirano M, Harada T, Mitsumori K, Yoshida A, Takahashi K, Nakashima N, Kitazawa T, Enomoto A, Inui K, and Shirasu Y (1987). Spontaneous tumors in F-344/Ducrj rats from 12 control groups of chronic and oncogenicity studies. J. Toxicol. Sci12: 111–126.
12.
12. Majka JA, Solleveld HA, Barthel CH, and Van Zwieten MJ (1990). Proliferative lesions of the pituitary in rats, E-2. In: Guides for Toxicologic PathologySTP/ARP/AFIP, Washington, DC.
13.
13. Mangnusson G, Majeed SK, and Gopinath C (1979). infiltrating pituitary neoplasms in the rat. Lab. Anim13:111–113.
14.
14. Mitsumori K (1989). Spontaneous tumors of the pituitary and adrenal glands in rats and mice. J. Toxicol. Pathol2:97–109 (in Japanese with English summary).
