Primary neoplasms of the kidneys occurred in 11/682 male (1.6%) and 2/694 female (0.3%) Crl:CD®Br strain Sprague-Dawley rats. Eight of 13 neoplasms were of mesenchymal origin and 5 of 13 were epithelial. Five neoplasms were lipoma (3) or liposarcoma (2). Three of 13 were either hemangioma (1) or mesenchymal tumors (2). The epithelial neoplasms were carcinomas. There was no microscopic evidence of metastasis among those neoplasms judged malignant on morphologic criteria. The overall natural incidence in males was nearly double that compiled for this strain while in females the incidence was similar to that reported for other females.
Anver MR, Cohen BJ, Lattuada CP, and Foster SJ (1982). Age-associated lesions in barrier-reared male Sprague-Dawley rats: A comparison between Hap : (SD) and Crl:COBS®CD®(SD) stocks. Exp. Ageing Res.8 No. 1: 3-24.
2.
Arison RN and Feudale EL (1967). Induction of renal tumour by streptozotocin in rats. Nature214: 1254-1255.
3.
Butler WH, Greenblatt M., and Lijinsky W. (1969). Carcinogenesis in rats by Aflatoxins B1, G1, and B2. Cancer Res.29: 2206-2211.
4.
Crain RC (1958). Spontaneous tumors in the Rochester strain of the Wistar rat. Am. J. Pathol. 34: 311-335.
5.
Flocks JS, Weis TP, Kleinman DC, and Kirsten WH (1965). Dose-response studies to polyoma virus in rats . J. Natl. Cancer Inst. 35: 259-284.
6.
Goodman DG, Ward JM, Squire RA, Chu KC, and Linhart MS (1979). Neoplastic and nonneoplastic lesions in aging F344 rats. Toxicol. Appl. Pharrnacol. 48: 237-248.
7.
Goodman DG, Ward JM, Squire RA, Paxton MB, Reichardt WD, Chu KC, and Linhart MS (1980). Neoplastic and nonneoplastic lesions in aging Osbome-Mendel rats. Toxicol. Appl. Pharmacol. 55: 433-447.
8.
Gordon LR (1986). Spontaneous lipomatous tumors in the kidney of the Crl:CD(SD)Br rat. Toxicol. Pathol. 14(2): 175-182.
9.
Hard GC and Butler WH (1970). Cellular analysis of renal neoplasia: Induction of renal tumors in dietary-conditioned rats by dimethylnitrosamine, with a reappraisal of morphological characteristics. Cancer Res. 30: 2796-2805.
10.
Hard GC (1976) Tumours of the kidney, renal pelvis and ureter . In: Pathology of Tumours in Laboratory Animals, VS Turusov (ed). IARC Scientific Publications No. 6, International Agency for Research on Cancer, World Health Organization, Lyon, France, pp. 73-90.
11.
Jasmin G. and Riopelle JL (1970). Nephroblastomas induced in ovariectomized rats by dimethylbenzanthracene. Cancer Res. 30: 321-326.
12.
Laquer GL and Matsumoto H. (1966). Neoplasms in female Fischer rats following intraperitoneal injection of methylazoxymethanol. J. Natl. Cancer Inst. 37: 217-232.
13.
Morris HP, Velat CA, and Wagner BP (1957). Carcinogenicity of some ingested acetylated mono- and diaminobiphenyl compounds in the rat. J. Natl. Cancer Inst. 18(1): 101-114.
14.
Morris JE, Price JM, Lalich JJ, and Stein RJ (1969). The carcinogenic activity of some 5-nitrofuran derivatives in the rat. Cancer Res. 29: 2145-2156.
15.
Riopelle JL and Jasmin G. (1969). Nature, classification, and nomenclature of kidney tumors induced in the rat by dimethylnitrosamine . J. Natl. Cancer Inst. 42: 643-662.
16.
Rosen VJ, Castanera TJ, Kimeldorf DJ, and Jones DC (1961). Renal neoplasms in the irradiated and nonirradiated Sprague-Dawley rat. Am. J. Pathol. 38: 359-368.
17.
Rosen VJ, Castanera TJKimeldorf DJ, and Jones DC (1962). Pancreatic islet cell tumors and renal tumors in the male rat following neutron exposure. Lab. Invest. 11(3): 204-210.
18.
Ross MH and Bras G. (1965). Tumor incidence patterns and nutrition in the rat. J. Nutrition87: 245-260.
19.
Schardein JL , Fitzgerald JE, and Kaump DH (1968). Spontaneous tumors in Holtzman-source rats of various ages. Pathol. Vet. 5: 238-252.
20.
Schoental R. , Hard GC, and Gibbard S. (1971). Histopathology of renal lipomatous tumors in rat treated with the "natural" products, pyrrolizidine alkaloids and α,β-unsaturated aldehydes. J. Natl. Cancer Inst. 47: 1037-1044.
21.
Snell, KC (1967). Renal disease of the rat. In: Pathology of Laboratory Rats and Mice, E Cotchin and FJC Rowe (eds). Blackwell Scientific Publications, Oxford and Edinburgh, England, pp. 131-142.
22.
Solleveld HA , Haseman JK, and McConnell EE (1984). Natural history of body weight gain, survival, and neoplasia in the F344 rat . J. Natl. Cancer Inst. 72(4): 929-940.
23.
Swann PF and Magee PN (1969). Induction of rat kidney tumours by ethyl methanesulphonate and nervous tissue tumours by methyl methanesulphonate and ethyl methanesulphonate . Nature223: 947-949.
24.
Thompson SW , Huseby RA, Fox MA, Davis CL, and Hunt RD (1961). Spontaneous tumors in the Sprague-Dawley rat. J. Natl. Cancer Inst. 27: 1037-1057.
25.
Ward JM, Hamlin MH, Ackerman LJ, Lattuada CP, Longfellow DG, and Cameron TP (1983). Age-related neoplastic and degenerative lesions in aging male virgin and ex-breeder ACI/segHapBr rats. J. Gerontol. 38(5): 538-548.
