Lead poisoning of unknown source was diagnosed histologically in 2 rhesus monkeys (Macaca mulatto) by finding acid-fast intranuclear inclusion bodies in the epithelial cells of renal cortical tubules. The presence of lead in the inclusions was determined by scanning electron microscopy/energy dispersive x-ray analysis using sections from paraffin embedded tissues. This observation indicates the usefulness of this technique for the detection and cellular localization of lead in tissues, even from archival material.
1. Carroll KG, Spinelli FR, and Goyer RA (1970). Electron probe microanalyser localization of lead in kidney tissue of poisoned rats. Nature227: 1056.
2.
2. Colle A, Grimaud JA, Boucherat M, and Manuel Y (1980). Lead poisoning in monkeys: Functional and histopathological alterations of the kidneys. Toxicology18:145–158.
3.
3. Ghadially FN and Yong NK (1976). Ultrastructural and x-ray analytical studies in intranuclear bismuth inclusions. Virchows Arch. [Cell Pathol]21:45–55.
4.
4. Goyer RA, May P, Cates MM, and Krigman MR (1970). Lead and protein content of isolated intranuclear inclusion bodies from kidneys of lead poisoned rats. Lab. Invest.22:245–251.
5.
5. Goyer RA and Rhyne BC (1973). Pathological effects of lead. Int. Rev. Exp. Pathol.12:1–71.
6.
6. Goyer RA and Wilson MH (1975). Lead induced inclusion bodies. Lab. Invest.32:149–156.
7.
7. Hausman R, Sturtevant RA, and Wilson WJ (1961). Lead intoxication in primates. J. Forensic Sci.6:180–196.
8.
8. Horn J (1970). Isolierung und Untersuchung von Ein-schlusskörperchen in der Rattenniere nach chronischer Bleivergiftung. Virchows Arch. [Cell Pathol]6:313–317.
9.
9. Houser WD and Frank N (1970). Accidental lead poisoning in a rhesus monkey (Macaca mulatto). J. Am. Vet. Med. Assoc.157:1919–1925.
10.
10. Hsu FS, Krook L, Shivery JN, Duncan JR, and Pond WG (1973). Lead inclusion bodies in osteoclasts. Science181:447–448.
11.
11. Kendall RJ and Scanlon PF (1985). Histology and ultrastructure of kidney tissue from ringed turtle doves that ingested lead. J. Environ. Pathol. Toxicol. Oncol.6:85–96.
12.
12. Locke LN, Baggley GE, and Irby HD (1966). Acid fast intranuclear inclusion bodies in the kidneys of mallards fed lead shot. Bull. Wildl. Dis. Assoc.2:127–131.
13.
13. McLeavey BJ (1977). Lead poisoning in dogs. NZ. Vet. J.25:395–396.
14.
14. Reed SJB (1975). Electron Probe Analysis.Cambridge University Press, London.
15.
15. Robbins SL, Cotran RS, and Kumar V (eds) (1984). Chemical and drug injury—Lead. In: Pathologic Basis of Disease, 3rd ed.W. B. Saunders Co., Philadelphia, PA, pp. 453–455.
16.
16. Skaar H, Ophus E, and Gullvag BM (1973). Lead accumulation within nuclei of moss leaf cells. Nature241:215–216.
17.
17. Sullivan ND (1985). The nervous system. In: Pathology of Domestic Animals, KVF Jubb, PC Kennedy, and N Palmer (eds). Academic Press, New York, NY, pp 201–338.
18.
18. Tsuchiya K (1979). Lead. In: Handbook on the Toxicology of Metals, 1st ed., L Friberg, GF Nordberg, and VB Vouk (eds). Elsevier/North Holland, Amsterdam, pp. 451–484.
19.
19. Vandeputte DF, Jacob WA, and Van Grieken RE (1990). Influence of fixation procedures on the microanalysis of lead-induced intranuclear inclusions in rat kidney. J. Histochem. Cytochem.38:331–337.
20.
20. White DJ (1977). Histochemical and histological effects of lead on the liver and kidney of the dog. Br. J. Exp. Pathol.58:101–112.
21.
21. Wolfseth R (1973). All You Want To Know About X-Ray Energy Spectrometry.Kevex Corporation, Burlingame, CA.
22.
22. Zook BC, Eisenberg JF, and McLanahan E. Some factors affecting the occurrence of lead poisoning in captive primates. J. Med. Primatol.2: 206–217.
23.
23. Zook BC, London WT, Sever JL, and Sauer RM (1976). Experimental lead paint poisoning in non-human primates. I. Clinical signs and course. J. Med. Primatol.5:23–40.
24.
24. Zook BC, Sauer RM, Bush M, and Gray CW (1973). Lead poisoning in zoo-dwelling primates. Am. J. Phys. Anthropol.38:415–424.
25.
25. Zook BC, Sauer RM, and Garner FM (1972). Lead poisoning in captive wild mammals. J. Wildl. Dis.8:264–272.
