Liver Lesions from Sex Steroids

Abstract

References

1. Baum JK , Holtz F , Bookstein JJ , Klein EW : Possible association between benign hepatomas and oral contraceptives. Lancet II: 926–929, 1973.

2. Grabowski M , Stenram U , Bergqvist A : Focal nodular hyperplasia of the liver, benign hepatomas, oral contraceptives and other drugs affecting the liver. Acta Pathol Microbiol Scand. Sect A 83:615–622, 1975.

3. Edmondson HA , Henderson B , Benton B : Liver-cell adenomas associated with the use of oral contraceptives. New Engl J Med 294: 470–472, 1976.

4. Klatskin G : Hepatic tumors: possible relationship to use of oral contraceptives. Gastroenterol 73: 386–394, 1977.

5. Rooks JB , Ory HN , Ishak KG et al: Epidemiology of hepatocellular adenoma. JAMA 242:644–648, 1979.

6. Vana J , Murphy GP , Aronoff BL , Baker HW : Survey of primary liver tumors and oral contraceptive use. J Toxicol Environ Health. 3: 255–273, 1979.

7. Squire RA , Levitt MH : Report of a workshop on classification of specific hepatocellular lesions in rats. Cancer Res 35: 3214–3223, 1975.

8. Histologic typing of liver tumors of the rat. JNCI 64:179–206, 1980.

9. Committe on Safety of Medicines : Carcinogenicity tests of oral contraceptives. Her Majesty's Stationary Office, London, 1972.

10.

10. Schuppler J , Guenzel P : Cyproterone acetate. Lancet II: 688, 1976.

11.

11. Schuppler J , Guenzel P : Liver tumors and steroid hormones in rats and mice. Arch Toxicol Suppl 2: 181–195, 1979.

12.

12. IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. 21:147–343, 1979.

13.

13. Gibson JP , Newberne JW , Kuhn WL , Elsa RJ : Comparative chronic toxicity of three oral estrogens in rats. Toxicol Appl Pharmacol 11: 489–510, 1967.

14.

14. Schardein JL , Kaump DH , Woosley ET , Jellema MA : Long-term toxicologic and tumorigenic studies on an oral contraceptive agent in albino rats. Toxicol Appl Pharmacol 16: 10–23, 1970.

15.

15. King TO , Lubansky J : Prolonged toxicity studies of a norethindrone-estrogen combination in rats. Pharmacologist 4: 176, 1962.

16.

16. McKinney GR , Weikel JH , Webb WK , Dick RG : Use of the life-table technique to estimate effects of certain steroids on probability of tumor formation in a long-term study in rats. Toxicol Appl Pharmacol 12: 68–79, 1968.

17.

17. Lang R , Redmann U : Non-mutagenicity of some sex hormones in the Ames' Salmonella/microsome mutagenicity test. Mutat Res 67: 361–365, 1979.

18.

18. Kappus H , Remmer H : Metabolic activation of norethisterone (norethindrone) to an irreversibly protein-bound derivative by rat liver microsomes. Drug Metab Disp 35: 338–344, 1975.

19.

19. Kappus H , Bolt HM : Irreversible protein binding of norethisterone (norethindrone) epoxide Steroids 27: 29–45, 1976.

20.

20. Kappus H , Bolt HM , Remmer H : Irreversible protein binding of metabolites of ethinylestradiol in vivo and in vitro. Steroids 22: 203–255, 1973.

21.

21. Bolt HM , Kappus H , Käsbohrer R : Metabolism of 17α-ethinylestradiol by human liver microsomes in vitro: aromatic hydroxylation and irreversible protein binding of metabolites. J Clin Endocrinol Metab 39: 1072–1080, 1974.

22.

22. Schillinger E, Prior G: Irreversible Bindung von Steroiden an Lebermikrosomen. Letter, date 5.5.1977.

23.

23. Bolt HM : Structural modifications in contraceptive steroids altering their metabolism and toxicity. Arch Toxicol 39: 13–19, 1977.

24.

24. Bolt HM , Kappus H : Irreversible binding of ethinylestradiol metabolites to protein and nucleic acids as catalysed by rat liver microsomes and mushroom tyrosinase. J Steroid Biochem 5: 179–184, 1974.

25.

25. Solt D , Farber E : New principle for the analysis of chemical carcinogenesis. Nature 283: 701–703, 1976.

26.

26. Tsuda H , Lee G , Farber E : Induction of resistant hepatocytes as a new principle for a possible short-term in vivo test for carcinogens. Cancer Res 40: 1157–1164, 1980.

27.

27. Peraino C , Fry RJ , Staffeldt E : Reduction and enhancement by phenobarbitol of hepatocarcinogenesis induced in the rat by 2-acetylanimofluorene. Cancer Res 31: 1506–1512, 1971.

28.

28. Peraino C , Fry RJ , Staffeldt E , Christopher JP : Comparative enhancing effects of phenobarbitol, amobarbitol, diphenylhydantoin and dichlorodiphenyl-trichloroethane on 2-acetylaminofluorene-induced hepatic tumorigenesis in the rat. Cancer Res 35: 2884–2890, 1975.

29.

29. Peraino C , Fry RJM , Staffeldt E , Christopher JP : Enhancing effects of phenobarbitone and butylated hydroxytoluene on 2-acetylaminofluorene-induced hepatic tumorigenesis in the rat. Food Cosmet Toxicol 15: 93–96, 1977.

30.

30. Neumann F , Elger W , Nishino Y , Steinbeck H : Probleme der Dosisfindung: Sexualhormone. Arzneim Forsch 27: 296–318, 1977.

31.

31. Argus MF , Hoch-Ligeti C , Arcos JC , Conney AH : Differential effects of ß-naphthoflavone and pregnenolone-16α-carbonitrile on diethylnitrosamine-induced hepatocarcinogenesis. J Natl Cancer Inst 61: 441–449, 1978.

32.

32. Taper HS : The effect of estradiol-17-phenylpropionate and estradiol benzoate on n-nitrosomorpholine induced liver carcinogenesis in ovariectomised female rats. Cancer 42: 462–467, 1978.

33.

33. Cameron R , Katsumi I , Ito N : Promotive effects of ethinyl estradiol in hepatocarcinogenesis by diethylnitrosamine in male rats. Gann 72: 339–340, 1981.

34.

34. Yager JD , Yager R : Oral contraceptive steroids as promotors of hepatocarcinogenesis in female Sprague-Dawley rats. Cancer Res 40: 3680–3685, 1980.

35.

35. Reuber MD , Firminger H : Effect of progesterone and diethylstilbestrol on hepatic carcinogenesis in A x C rats fed N-2-fluorenyldiacetamide. JNCI 29: 933–938, 1962.

36.

36. Stasny J , Paschkis KE , Cantarow A , Rothenberg MS : Neoplasms in rats with 2-acetaminofluorene and sex hormones. Cancer Res 7: 356–362, 1947.

37.

37. Toh Y-C : Systemic effect of testosterone on rat liver tumor induction by n-2-fluorenylacetamide. JNCI 48: 113–118, 1972.

38.

38. Cantarow A , Paschkis KE , Stasney J , Rothenberg MS : The influence of sex hormones upon the hepatic lesions produced by 2-acetaminofluorene. Cancer Res 6: 610–616, 1946.

39.

39. Schulte-Hermann R : Induction of liver growth by xenobiotic compounds and other stimuli. Crit Rev Toxicol 3: 97–186, 1974.

40.

40. Schulte-Hermann R : Reactions of the liver to injury: adaption in Toxic Injury of the Liver. Farber E (editor). Marcel Decker, New York, 1979, p. 385.

41.

41. Ohde G , Schuppler J , Schulte-Hermann R , Keiger H : Proliferation of rat liver cells in preneoplastic nodules after stimulation of liver growth by xenobiotic Inducers. Arch Toxicol Suppl. 2:451–455, 1979.

42.

42. Schulte-Hermann R , Ohde G , Schuppler J , Timmermann-Trosiener I : Enhanced proliferation of putative preneoplastic cells in rat liver following treatment with the tumor promotors phenobarbitol, hexachlorocyclohexane, steroid compounds and nafenopin. Cancer Res. 41:2556–2562, 1981.

43.

43. Schulte-Hermann R , Schuppler J , Ohde G , Timmermann-Trosiener I : Effect of tumor promotors on proliferation of putative preneoplastic cells in rat liver in Carcinogenesis, Vol 7. Hecker E (editor). Raven Press, New York, pp. 99–104.

44.

44. Ogawa K , Onoe T , Takenchi M : Spontaneous occurrence of γ-glutamyl transpeptidase positive hepatocytic foci in 105-week-old Wistar and 72-week-old Fischer 344 male rats. JNCI 67: 407–412, 1981.

45.

45. Weisburger JH , Williams GM : Carcinogen Testing: Current problems and new approaches. Science 214: 401–407, 1981.

46.

46. Düsterberg B , Hümpel M , Speck U : Terminal half-lives in plasma and bioavailability of norethisterone, levornorgestrel, cyproterone acetate and gestodene in rats, beagles and monkeys. Contraception 24(6):673–683, 1981.

47.

47. Back DJ , Breckenridge AM , Crawford FE , Orme ML , Rowe PH , Smith E : First pass effect of norethindrone in rabbits and rats. J Pharmacol Exp Ther 207: 555–565, 1978.

48.

48. OCs-Update on usage, safety and side effects. Population Reports A5, January 1979.

49.

49. Royal College of General Practitioners Oral Contraception Study : Further analyses of mortality in oral contraceptive users. Lancet 1:541–1207, 1981.

50.

50. Edmondson HA: Tumors of the liver and intrahepatic bile ducts. Atlas of tumor pathology, Section VII, Fascicle 25, AFIP, 1958.

51.

51. Chu KC , Cipriano C , Ward JM : Factors in the evaluation of 200 NCI carcinogen bioassays. J Toxicol Environ Health 8: 251–280, 1981.

52.

52. Pollak H : Spontanruptur eines Leberadenoms nach langjähriger Einnahme eines Antikonzeptivums. Münch Med Wochenschr 121: 93–94, 1979.

53.

53. Noble RC : The development of prostatic adenocarcinoma in Nb rats following prolonged sex hormone administration. Cancer Res 37: 1929–1933, 1977.

54.

54. Reuber MD : Effect of age and testosterone on the induction of hyperplastic nodules, carcinomas and cirrhosis of the liver in rats ingesting N-2-fluorenyldiacetamide. Eur J Cancer 12: 137–141, 1976.

55.

55. Sher PS , Jensen RD , Bokelman DL : Spontaneous tumors in control F 344 and Charles River-CD rats and Charles River CD-1 and B6C3HF1 mice. Toxicol Lett 11: 103–110, 1982.

56.

56. Epstein SS , Arnold E , Andrea T , Bass W , Bishop Y : Detection of chemical mutagens by the dominant lethal assay in the mouse. Toxicol Appl Pharmacol 23: 288–325, 1972.

57.

57. Wanless IR , Medline A : Roll of estrogens as promoters of hepatic neoplasia. Lab Invest 46: 313–320, 1982.

58.

58. Schuppler J , Dammé J , Schulte-Hermann R : Assay of some endogenous and synthetic sex steroids for tumor initiating activity in rat liver using the Solt-Faber system. Carcinogenesis 4:239–241, 1983.