A retrospective study was conducted to determine the incidence of granular cell tumors of the brain in ChR-CD rats, used as controls in two-year toxicity studies conducted at Haskell Laboratory (1971-73). Two (1.6%) such tumors were found in 127 male rats, 13 to 25 months of age. No granular cell tumors of the brain were found in 128 female ChR-CD rats, 13 to 25 months of age. These appear to be the first reported cases of granular cell tumors of the brain in this strain of Sprague-Dawley rat.
References
1.
1. Stout AP, Raffaele L: Granular cell tumor in: Atlas of Tumor Pathology, 2nd Series, Fasicle 1, Tumors of the Soft Tissues. Armed Forces Institute of Pathology, Washington, D.C., 1967.
2.
2. Abrikossoff AL: über myome ausgenemd von der guergestrieften wullkürliehen Muskulatur. Virchows Arch Pathol Anat260:215–233, 1926.
3.
3. Markesbery WR, Duffy PE, Coven D: Granular cell tumors of the central nervous system.Neuropathol Exp Neurol32:92–109, 1973.
7. Troy MA: Granular cell myoblastoma in a dog. J Am Vet Med Assoc126:397, 1955.
8.
8. Alexander JE, Keown GA, Palotary JL: Granular cell myoblastoma with hypertrophic pulmonary osteoarthropathy in a mare. J Am Vet Med Assoc146: 703–708, 1965.
9.
9. Misdorp W, Nauta-Van Gelder HL: “Granular-cell Myoblastoma” in the horse—a report of 4 cases.Pathol Vet5:385–394, 1968.
10.
10. Swaen GJV, Becker AE: Granular-cell myoblastoma of the pituitary gland in an old rat: A case report.Lab Anim2:41–43, 1968.
11.
11. Jones EL, Searle CE, Thomas Smith W: Tumors of the nervous system of N-ethyl-N-nitrosourea.J Pathol109:123–139, 1973.
12.
12. Dunn TB, Green AW: Cysts of the epidermis, cancer of the cervix, granular cell myoblastoma, and other lesions after estrogen injection in newborn mice.J Natl Cancer Inst32:425–455, 1963.
13.
13. Hollander CF, Burek JD, Boorman GA, Snell KC, Laquer GL: Granular cell tumors of the central nervous system of rats.Arch Pathol Lab Med100:445–447, 1976.
14.
14. Burek JD: Granular cell tumors. In CRC Review of Pathology of Aging Rats, 1978. CRC Press, Inc. West Palm Beach, Florida.
15.
15. Chen HC, Sigler FW, Van Petten LE: Spontaneous brain tumors of Long-Evans rats: A report of four granular cell tumors (unpublished, 1976).
16.
16. Berman JJ, Rice JM, Strandberg J: Granular cell variants in a rat schwannoma.Vet Pathol15:725–731, 1978.
17.
17. Sobel HJ, Schwarz R, Marquet E: Light-and electron-microscopic study of the origin of granular-cell myoblastoma.J Pathol109:101–111, 1972.
