Naturally Occurring Granular Cell Tumors of the Brain in Rats

Abstract

A retrospective study was conducted to determine the incidence of granular cell tumors of the brain in ChR-CD rats, used as controls in two-year toxicity studies conducted at Haskell Laboratory (1971-73). Two (1.6%) such tumors were found in 127 male rats, 13 to 25 months of age. No granular cell tumors of the brain were found in 128 female ChR-CD rats, 13 to 25 months of age. These appear to be the first reported cases of granular cell tumors of the brain in this strain of Sprague-Dawley rat.

References

1. Stout AP , Raffaele L : Granular cell tumor in: Atlas of Tumor Pathology, 2nd Series, Fasicle 1, Tumors of the Soft Tissues. Armed Forces Institute of Pathology, Washington, D.C., 1967.

2. Abrikossoff AL : über myome ausgenemd von der guergestrieften wullkürliehen Muskulatur. Virchows Arch Pathol Anat 260:215–233, 1926.

3. Markesbery WR , Duffy PE , Coven D : Granular cell tumors of the central nervous system. Neuropathol Exp Neurol 32:92–109, 1973.

4. Murphy, GH , Dockerty MD , Broders AC : Myoblastoma. Am J Pathol 25:1157–1178, 1949.

5. Bangle R : An early granular-cell myoblastoma confined within a small peripheral myelinated nerve. Cancer 6:790–793, 1953.

6. Budzilovich GN : Granular cell “myoblastoma” of vagus nerve. Acta Neuropathol 10:162–165, 1968.

7. Troy MA : Granular cell myoblastoma in a dog. J Am Vet Med Assoc 126:397, 1955.

8. Alexander JE , Keown GA , Palotary JL : Granular cell myoblastoma with hypertrophic pulmonary osteoarthropathy in a mare. J Am Vet Med Assoc 146: 703–708, 1965.

9. Misdorp W , Nauta-Van Gelder HL : “Granular-cell Myoblastoma” in the horse—a report of 4 cases. Pathol Vet 5:385–394, 1968.

10.

10. Swaen GJV , Becker AE : Granular-cell myoblastoma of the pituitary gland in an old rat: A case report. Lab Anim 2:41–43, 1968.

11.

11. Jones EL , Searle CE , Thomas Smith W : Tumors of the nervous system of N-ethyl-N-nitrosourea. J Pathol 109:123–139, 1973.

12.

12. Dunn TB , Green AW : Cysts of the epidermis, cancer of the cervix, granular cell myoblastoma, and other lesions after estrogen injection in newborn mice. J Natl Cancer Inst 32:425–455, 1963.

13.

13. Hollander CF , Burek JD , Boorman GA , Snell KC , Laquer GL : Granular cell tumors of the central nervous system of rats. Arch Pathol Lab Med 100:445–447, 1976.

14.

14. Burek JD : Granular cell tumors. In CRC Review of Pathology of Aging Rats, 1978. CRC Press, Inc. West Palm Beach, Florida.

15.

15. Chen HC, Sigler FW, Van Petten LE: Spontaneous brain tumors of Long-Evans rats: A report of four granular cell tumors (unpublished, 1976).

16.

16. Berman JJ , Rice JM , Strandberg J : Granular cell variants in a rat schwannoma. Vet Pathol 15:725–731, 1978.

17.

17. Sobel HJ , Schwarz R , Marquet E : Light-and electron-microscopic study of the origin of granular-cell myoblastoma. J Pathol 109:101–111, 1972.