A large subcutaneous mass was observed at necropsy in the right neck area of a 95-week-old female Fischer 344 rat that served as an untreated control animal in a 2-year carcinogenicity study. Formalin-fixed, paraffin-embedded sections of the mass were stained with hematoxylin and eosin along with the immunohistochemical biomarkers lactoperoxidase, catalase, and amylase. Based on its histomorphological and immunohistochemical features, the lesion was diagnosed as a carcinoma of the extraorbital lacrimal gland.
Botts S., Jokinen M., Gaillard ET, Elwell MR, Mann PC ( 1999). Salivary, Harderian, and lacrimal glands. In: Pathology of the Mouse, Maronpot RR (ed). Cache River Press, Vienna , Illinois, pp 49-79.
2.
Cavallero C. (1967). Relative effectiveness of various steroids in an androgen assay using the exorbital lacrimal gland of the castrated rat. Acta Endocrinol55: 119-130.
3.
Chiasson RB (1988). Special sense organs. In: Laboratory Anatomy of the White Rat, Chiasson RB. WCBrown, Dubuque, Iowa, pp 103-108.
4.
Dawe CJ (1979). Tumors of the salivary and lachrymal glands, nasal fossa and maxillary sinuses. In: Pathology of Tumours in Laboratory Animals, Vol 2: Tumours of the Mouse, Turusov VS (ed). IARC Scientific Publication No 23, Lyon, France, pp 91-133.
5.
Elwell MR, Leininger JR (1990). Tumors of the salivary and lacrimal glands. In: Pathology of Tumors in Laboratory Animals, Vol 1: Tumors of the Rat, Turusov VS, Mohr U (eds). IARC Scientific Publication No 99, Lyon, France, pp 89-107.
6.
Mansson-Rahemtulla B., Rahemtulla F., Humphreys-Beher MG (1990). Human salivary peroxidase and bovine lactoperoxidase are cross-reactive. J Dent Res69: 1839-1846.
7.
Pruitt B., Rahemtulla F., Russell M. (1999). Innate humoral factors. In: Mucosal Immunology, Vol 2, Ogra PL, Mestecky J, Lamm ME, et al (eds). Academic Press, New York, pp 65-88.
8.
Van Haeringen NJ, Thorlig L. (1985). Enzymology of tear fluid . In: Protides of the Biological Fluids, Peters H (ed). Pergamon Press, Oxford, pp 399-401.
9.
Walker R. (1958). Age changes in the rat's exorbital lacrimal gland . Anat Rec132: 49-69.
10.
Yoshitomi K. , Boorman GA (1990). Eye and associated glands . In: Pathology of the Fischer Rat, Montgomery CA , Eustis SL, Elwell MR, Montgomery CA , MacKenzie WF (eds). Academic Press, San Diego, California, pp 239-259.
