Identifying how biological parameters change with age can provide insights into the physiological determinants of disease and, ultimately, death. Most prior studies of age-related change in biomarkers are based on cross-sectional data, small or selective samples, or a limited number of biomarkers. We use data from a nationally representative longitudinal sample of 639 Taiwanese aged 54 and older in 2000 to assess changes over a six-year period in a wide range of biomarkers. Markers that increased most with age were glycoslyated hemoglobin, interleukin-6, and norepinephrine. Markers that decreased most with age were diastolic blood pressure and creatinine clearance. For example, glycoslyated hemoglobin increased by 8% to 13%, depending on sex and age at baseline, over this six-year period. Several standard clinical risk factors exhibited little evidence of age-related change. Further research is needed to determine whether the observed variation between individuals in biomarker changes represents differences in underlying physiological function that are predictive of future health and survival.
Bakx, J.C., H.J. van den Hoogen, P. Deurenberg, J. van Doremalen, and W.J. van den Bosch .2000. "Changes in Serum Total Cholesterol Levels Over 18 Years in a Cohort of Men and Women: The Nijmegen Cohort Study."Preventive Medicine30(2):138-45.
2.
Boss, G.R. and J.E. Seegmiller.1981. "Age-related Physiological Changes and Their Clinical Significance."The Western Journal of Medicine135(6):434-40.
3.
Bruunsgaard, H.2002. "Effects of Tumor Necrosis Factor-alpha and Interleukin-6 in Elderly Populations." European Cytokine Network13(4):389-91.
4.
Burt, V.L., P. Whelton, E.J. Roccella, C. Brown, J.A. Cutler, M. Higgins, M.J. Horan, and D. Labarthe.1995. "Prevalence of Hypertension in the US Adult Population. Results From the Third National Health and Nutrition Examination Survey, 1988-1991."Hypertension25(3):305-13.
5.
Chiu, K.C., D.S. Martinez, and A. Chu.2005. "Comparison of the Relationship of Age and Beta Cell Function in Three Ethnic Groups." Clinical Endocrinology62(3):296-302.
6.
Cockcroft, D.W. and M.H. Gault.1976. "Prediction of Creatinine Clearance From Serum Creatinine ." Nephron16(1):31-41.
7.
Crimmins, E., S. Vasunilashorn, J.K. Kim, and D. Alley.2008. "Biomarkers Related to Aging in Human Populations." Advances in Clinical Chemistry46:161-216.
8.
Danesh, J., R. Collins, P. Appleby, and R. Peto.1998. "Association of Fibrinogen, C-reactive Protein, Albumin, or Leukocyte Count With Coronary Heart Disease: Meta-analyses of Prospective Studies." JAMA: The Journal of the American Medical Association279(18):1477-482.
9.
Elia, M.2001. "Obesity in the Elderly."Obesity Research9 (Suppl 4):244S-48S.
10.
Frishman, W.H., W.L. Ooi, M.P. Derman, H.A. Eder, L.I. Gidez, D. Ben-Zeev, P. Zimetbaum, M. Heiman, and M. Aronson.1992. "Serum Lipids and Lipoproteins in Advanced Age. Intraindividual Changes." Annals of Epidemiology2(1-2):43-50.
11.
Gerlo, E.A., D.F. Schoors, and A.G. Dupont.1991. "Age- and Sex-related Differences for the Urinary Excretion of Norepinephrine, Epinephrine, and Dopamine in Adults."Clinical Chemistry37(6):875-78.
12.
Gillum, R.F.2000. "Assessment of Serum Albumin Concentration as a Risk Factor for Stroke and Coronary Disease in African Americans and Whites." Journal of the National Medical Association92(1):3-9.
13.
Goldman, N., I.F. Lin, M. Weinstein, and Y.H. Lin.2003. "Evaluating the Quality of Self-reports of Hypertension and Diabetes."Journal of Clinical Epidemiology56(2):148-54.
14.
Grunenberger, F., C.J. Lammi-Keefe, J.L. Schlienger, J.P. Deslypere, and J.G. Hautvast.1996. "Longitudinal Changes in Serum Lipids of Elderly Europeans. SENECA Investigators." European Journal of Clinical Nutrition50 (Suppl 2):S25-31.
15.
Hughes, V.A., R. Roubenoff, M. Wood, W.R. Frontera, W.J. Evans, and M. A. Fiatarone Singh.2004. "Anthropometric Assessment of 10-y Changes in Body Composition in the Elderly."The American Journal of Clinical Nutrition80(2):475-82.
16.
James, K., L.R. Weitzel, C.D. Engelman, G. Zerbe, J.M. Norris, and Framingham Heart Study.2003. "Genome Scan Linkage Results for Longitudinal Systolic Blood Pressure Phenotypes in Subjects From the Framingham Heart Study."BMC Genetics 4 (Suppl 1):S83.
17.
Jenner, D.A., G.A. Harrison, I.A. Prior, D.L. Leonetti, and W.Y. Fujimoto.1987. "24-h Catecholamine Excretion: Relationships With Age and Weight."Clinica Chimica Acta; International Journal of Clinical Chemistry164(1):17-25.
18.
Karlamangla, A.S., B.H. Singer, and T.E. Seeman.2006. "Reduction in Allostatic Load in Older Adults Is Associated With Lower All-cause Mortality Risk: MacArthur Studies of Successful Aging."Psychosomatic Medicine68(3):500-07.
19.
Kilpatrick, E.S., M.H. Dominiczak, and M. Small.1996. "The Effects of Ageing on Glycation and the Interpretation of Glycaemic Control in Type 2 Diabetes." QJM: Monthly Journal of the Association of Physicians89(4):307-12.
20.
Landahl, S., C. Bengtsson, J.A. Sigurdsson, A. Svanborg, and K. Svardsudd.1986. "Age-related Changes in Blood Pressure ." Hypertension8(11):1044-049.
21.
Lindeman, R.D., J. Tobin, and N.W. Shock.1985. "Longitudinal Studies on the Rate of Decline in Renal Function With Age." Journal of the American Geriatrics Society33(4):278-85.
22.
Lissner, L., L. Sjostrom, C. Bengtsson, C. Bouchard, and B. Larsson.1994. "The Natural History of Obesity in an Obese Population and Associations With Metabolic Aberrations." International Journal of Obesity and Related Metabolic Disorders: Journal of the International Association for the Study of Obesity18(6):441-47.
23.
Noppa, H., M. Andersson, C. Bengtsson, A. Bruce, and B. Isaksson.1980. "Longitudinal Studies of Anthropometric Data and Body Composition. The Population Study of Women in Gotenberg, Sweden."The American Journal of Clinical Nutrition33(1):155-62.
24.
Nuttall, F.Q.1999. "Effect of Age on the Percentage of Hemoglobin A1c and the Percentage of Total Glycohemoglobin in Non-diabetic Persons." The Journal of Laboratory and Clinical Medicine134(5):451-53.
25.
Roubenoff, R., T.B. Harris, L.W. Abad, P.W. Wilson, G.E. Dallal, and C.A. Dinarello.1998. "Monocyte Cytokine Production in an Elderly Population: Effect of Age and Inflammation." The Journals of Gerontology, Series A, Biological Sciences and Medical Sciences53(1):M20-6.
26.
Rowe, J.W., R. Andres, J.D. Tobin, A.H. Norris, and N.W. Shock.1976. "The Effect of Age on Creatinine Clearance in Men: A Cross-sectional and Longitudinal Study."Journal of Gerontology31(2):155-63.
27.
Schalk, B.W., M. Visser, M.A. Bremmer, B.W. Penninx, L.M. Bouter, and D.J. Deeg.2006. "Change of Serum Albumin and Risk of Cardiovascular Disease and All-cause Mortality: Longitudinal Aging Study Amsterdam."American Journal of Epidemiology164(10):969-77.
28.
Schubert, C.M., N.L. Rogers, K.E. Remsberg, S.S. Sun, W.C. Chumlea, E.W. Demerath, S.A. Czerwinski, B. Towne, and R.M. Siervogel.2006. "Lipids, Lipoproteins, Lifestyle, Adiposity and Fat-free Mass During Middle Age: The Fels Longitudinal Study."International Journal of Obesity30(2):251-60.
29.
Shimokata, H., R. Andres, P.J. Coon, D. Elahi, D.C. Muller, and J.D. Tobin.1989. "Studies in the Distribution of Body Fat. II. Longitudinal Effects of Change in Weight." International Journal of Obesity13(4):455-64.
30.
Siervogel, R.M., W. Wisemandle, L.M. Maynard, S.S. Guo, A.F. Roche, W.C. Chumlea, and B. Towne.1998. "Serial Changes in Body Composition Throughout Adulthood and Their Relationships to Changes in Lipid and Lipoprotein Levels. The Fels Longitudinal Study."Arteriosclerosis, Thrombosis, and Vascular Biology18(11):1759-764.
31.
Sparkman, N.L. and R.W. Johnson.2008. "Neuroinflammation Associated With Aging Sensitizes the Brain to the Effects of Infection or Stress." Neuroimmunomodulation15(4-6):323-30.
32.
StataCorp.2007. Stata Statistical Software: Release 10. College Station, TX: StataCorp LP.
33.
Ueno, L.M., Y. Yamashita, T. Moritani, and E. Nakamura.2003. "Biomarkers of Aging in Women and the Rate of Longitudinal Changes." Journal of Physiological Anthropology and Applied Human Science22(1):37-46.
34.
Weijenberg, M.P., E.J. Feskens, and D. Kromhout.1996. "Age-related Changes in Total and High-density-lipoprotein Cholesterol in Elderly Dutch Men." American Journal of Public Health86(6):798-803.
35.
Wilson, P.W., K.M. Anderson, T. Harris, W.B. Kannel, and W.P. Castelli.1994. "Determinants of Change in Total Cholesterol and HDL-C With Age: The Framingham Study."Journal of Gerontology49(6):M252-7.
36.
Yashin, A.I., I.V. Akushevich, K.G. Arbeev, L. Akushevich, S.V. Ukraintseva, and A. Kulminski.2006. "Insights on Aging and Exceptional Longevity From Longitudinal Data: Novel Findings From the Framingham Heart Study."Age (Dordrecht, Netherlands)28(4):363-74.
37.
Yates, A.P. and I. Laing.2002. "Age-related Increase in Haemoglobin A1c and Fasting Plasma Glucose Is Accompanied by a Decrease in Beta Cell Function Without Change in Insulin Sensitivity: Evidence From a Cross-sectional Study of Hospital Personnel." Diabetic Medicine: A Journal of the British Diabetic Association19(3):254-58.
38.
Zamboni, M., G. Mazzali, E. Zoico, T.B. Harris, J.B. Meigs, V. Di Francesco, F. Fantin, L. Bissoli, and O. Bosello.2005. "Health Consequences of Obesity in the Elderly: A Review of Four Unresolved Questions." International Journal of Obesity29(9):1011-029.
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