Biochemical reactors pose special problems in that they are essentially concerned with living systems. The consequences of this is that the bio transformations are complex and require detailed consideration, especially since instabilities can easily occur if the concentration of species is not controlled carefully. A discussion of the issues is presented and the principal factors identified. This is then used as a basis for analysing the dynamic models suitable for state variable models for on-line computer control.
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References
1.
Atkinson, S.B. and Mavituna, F.1983. Biochemical Engineering and Biotechnology Handbook , p 487, Macmillan Publishers.
2.
Constantinides, A. and Gaden, E.1970. 'Optimisation of a penicillin fermentation', Biotechnol and Bioeng, 12, 803-830.
3.
Canovas-Diaz, M. and Howell, J.A.1985. 'A stratified mixed culture biofilm model for anaerobic digestion', IChemE Symposium Multi-Stream 85, City University.
4.
Ghoul, M., Pons, M.N., Engasser, J.M. and Bordet, J.1985. 'Extended Kalman filtering technique for the on-line control of Candida utilis production'. In 'Modelling and control of biotechnological processes', Ist IFAC Symposium , Nordwijkerhout.
5.
Howell, J.A.1979. 'Alternatives to activated sludge'. In ' The oil industry and microbial ecosystems', Heyden and Sons, London.
6.
Howell, J.A. and Jones, M.G.1982. 'Problems in on-line parameter estimation for a structured model'. In 'Computer applications in fermentation technology ', SCI London.
7.
Reuss, M. and Brammer, U.1985. 'Influence of substrate distribution on production'. In 'Computer controlled bakers yeast production'. In 'Computer applications in fermentation technology', SCI London.
8.
Slott, S., Madsen, G. and Norman, B.E.1974. Application of Heat Stable Bacterial Amylase in the Starch Industry, in Enzyme Engineering, Vol 2, ed by E. K. Pye and L. B. Wingard jun, p 17. Plenum Press, New York.