ReynoldsE.. Do anticonvulsants alter the natural course of epilepsy? Treatment should be started as soon as possible.BMJ1995; 310: 176–7
2.
ChadwickD.. Do anticonvulsants alter the natural course of epilepsy?: Case for early treatment is not established.BMJ1995; 310: 177–8
3.
ReynoldsE., ElwesR., ShorvonS.. Why does epilepsy become intractable? Prevention of chronic epilepsy.Lancet1983; ii: 952–4
4.
GowersW.. Epilepsy and Other Chronic Convulsive Diseases.London: Churchill, 1881
5.
RodinE.. The Prognosis of Patients with Epilepsy.Springfield, IL: Charles C Thomas, 1968
6.
AnnegersJ., HauserW., ElvebackL.. Remission of seizures and relapse in patients with epilepsy.Epilepsia1979; 20: 729–37
7.
ElwesR., JohnsonA., ShorvonS., ReynoldsE.. The prognosis for seizure control in newly diagnosed epilepsy.N Engl J Med1984; 311: 944–7
8.
ElwesR., JohnsonA., ReynoldsE.. The course of untreated epilepsy.BMJ1988; 297: 948–50
9.
LoiseauP., DucheB., CordovaS., DartiguesJ., CohadonS.. Prognosis of benign childhood epilepsy with centrotemporal spikes: a follow up of 168 patients.Epilepsia1988; 29: 229–35
10.
VerityC., GoldingJ.. Risk of epilepsy after febrile convulsions: a national cohort study.BMJ1991; 303: 1373–6
11.
AnnegersJ., HauserW., ShirtsS., KurlandL.. Factors prognostic of unprovoked seizures after febrile convulsions.N Engl J Med1987; 316: 493–8
12.
MeldrumB., BrierlyJ.. Prolonged epileptic seizures in primates: ischaemic cell change and its relationship to ictal physiological events.Arch Neurol1973; 28: 10–17
13.
SagarH., OxburyJ.. Hippocampal neuron loss in temporal lobe epilepsy: correlation with early childhood convulsions.Ann Neurol1987; 22: 334–40
14.
KeranenT., RiekkinenP.. Remission of untreated epilepsy.BMJ1993; 307: 483
15.
PlacenciaM., ShorvonS., ParedesV.Epileptic seizures in an Andean region of Ecuador: incidence and prevalence and regional variation.Brain1992; 115: 771–82
16.
OsuntokunB., AdeujaA., NottidgeV.Prevalence of the epilepsies in Nigerian Africans: a community-based study.Epilepsia1987; 28: 272–9
17.
Tekle-HaimanotR., ForsgrenL., AbebeM.Clinical and electroencephalographic characteristics of epilepsy in rural Ethiopia: a community-based study.Epilepsy Res1990; 7: 230–9
18.
TemkinN., DikmenS., WilenskyA., KeihmJ., ChabalS., WinnH.. A randomized double-blind study of phenytoin for the prevention of post traumatic seizures.N Engl J Med1990; 323: 497–502
19.
CamfieldP., CamfieldC., DooleyJ., SmithE., GarnerB.. A randomized study of carbamazepine versus no medication after a first unprovoked seizure in childhood.Neurology1989; 39: 851–2
20.
First seizure trial group. Randomized clinical trial on the efficacy of antiepileptic drugs in reducing the risk of relapse after a first unprovoked tonic clonic seizure.Neurology1993; 43: 478–83
21.
FeksiA., KaamugishaJ., GatitiS., SanderJ., ShorvonS.. Comprehensive primary health care antiepileptic drug treatment in rural and semi-urban Kenya.Lancet1991; 337: 406–9
22.
PlacenciaM., SanderJ., ShorvonS.Antiepileptic drug treatment in a community health care setting in northern Ecuador: a prospective 12 month assessment.Epilepsy Res1993; 14: 237–44
23.
WattsA.. The natural history of untreated epilepsy in a rural community in Africa.Epilepsia1992; 33: 464–8
24.
MattsonR., CramerJ., CollinsJ.Comparison of carbamazepine, phenobarbital, phenytoin, and primidone in partial and secondarily generalized tonic-clonic seizures.N Engl J Med1985; 313: 145–51
25.
GoddardG.. Development of epileptic seizures through brain stimulation at low intensity.Nature1967; 214: 1020–1
26.
RacineR.. Modification of seizure activity by electrical stimulation. II Motor seizure.Electroencephalogr Clin Neurophysiol1972; 32: 281–94
27.
WasterlainC., JonecV.. Chemical kindling by muscarinic amygdaloid stimulation in the rat.Brain Res1983; 271: 311–23
28.
HirschE., VergnesM., NehligA., SimlerS., MatonB., MarescauxC.. The amygdala is critical for electrocortical expression of kindled seizures.Epilepsia1994; 35(Suppl 8): 37
29.
Ben-AriY.. Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy.Neuroscience1985; 14: 375–403
30.
NadlerJ., PerryB., CotmanC.. Selective reinnervation of hippocampus area CA1 and the fascia dentata after destruction of CA3-CA4 afferents with kainic acid.Brain Res1980; 182: 1–9
31.
SutulaT., HeX., CavazosJ., ScottG.. Synaptic reorganization induced in the hippocampus by abnormal functional activity.Science1988; 239: 1147–150
32.
SutulaT., CascinoG., CavazosJ., ParadaI., RamirezL.. Mossy fiber synaptic reorganization in the epileptic human temporal lobe.Ann Neurol1989; 26: 321–30
33.
SutulaT.. Experimental models of temporal lobe epilepsy: new insights from the study of kindling and synaptic reorganization.Epilepsia1990; 31(Suppl 3): S45–54
LowrieM., EttlingerG.. The development of independent secondary (“mirror”) discharges in the monkey: failure to replicate earlier findings.Epilepsia1980; 21: 25–30
36.
HarrisA., LockardJ.. Absence of seizures or mirror foci in experimental epilepsy after excision of alumina and astrogliotic scar.Epilepsia1981; 22: 107–22
37.
MorrellF.. Secondary epileptogenesis in man.Arch Neurol1985; 42: 318–35
38.
SanderJ.. Some aspects of prognosis in the epilepsies: a review.Epilepsia1993; 34: 1007–16