Fifty-three patients with multiple sclerosis were assessed in a double-blind multicentre study for the effect of amantadine. The patients were observed in general practices for up to four years. Relapses occurred in 5 of the 24 patients treated with amantadine and in 14 of the 29 placebo-treated patients. Neurological deterioration was not significantly different in the two groups.
MillerH.. Three great neurologists. In: ShawR.M., BowenR., PagetG.E., eds. All heal.London: Heinemann, 1971: 97–111
2.
McDonaldW.I.. The mystery of the origin of multiple sclerosis.J Neurol Neuroaurg Psychiatry1986; 49: 113–23
3.
FieldE.J., JoyceG.. Screening of children at risk of multiple sclerosis.Lancet1977; ii: 141
4.
PatyD.N., CousinsH.K., ReadS., AdlakhaK.. Linoleic acid in multiple sclerosis - failure to show any therapeutic benefit.Acta Neurol Scand1978; 58: 53–8
5.
MertinJ., RudgeP., KremerM.Double-blind controlled trial of immunosuppression in multiple sclerosis: Final report.Lancet1982; ii: 351–4
6.
JamesW.H.. Concordance in twins of multiple sclerosis.Lancet1983; i: 690
CarpR.I., LicursiP.C., MerzP.A.Decreased percentage of polymorphonuclear neutrophils in mouse peripheral blood after inoculation with material from multiple sclerosis patients.J Exp Med1972; 136: 618–29
9.
StephensonJ.R., MeulenW.T., KieslingW.. Search for canine distemper virus in multiple sclerosis.Lancet1980; ii: 772–5
PethakS., WebbH.L.. Paramyxovirus-like inclusions in brain of patients with severe multiple sclerosis.Lancet1976; i: 111
12.
PrasadL., BroomeJ.D., PartachukL.P., GuptaJ., CookA.W.. Recovery of paramyxovirus from the jejunum of patients with multiple sclerosis.Lancet1977; i: 1117–23
13.
MitchellD.N., PorterfieldJ.S., MichelettiR.Isolation of an infectious agent from bone marrow of patients with multiple sclerosis.Lancet1978; ii: 387–91
14.
RaneE.H., BrookeB.N., Herman-TaylorJ.. Association of ulcerative colitis with multiple sclerosis.Lancet1981; ii: 155
15.
ShepherdD.I., DowneA.W.. A further prevalence of multiple sclerosis in North-East Scotland.J Neurol Neurosurg Psychiatry1980; 43: 310–15
16.
AchesonE.D.. Epidemiology of multiple sclerosis.Br Med Bull1977; 33: 9–14
17.
AlterM.. Is multiple sclerosis an age-dependent host response to measles.Lancet1976; i: 450–7
18.
GayD., DickG., UptonG.. Multiple sclerosis associated with sinusitis: Case-controlled study in general practice.Lancet1986; i: 815–19
19.
KurtzkeJ.F., HyllestedK.. Multiple sclerosis in the Faroe Islands.Neurology1986; 36: 307–28
20.
SchapiraM.. Treating multiple sclerosis with Amantadine hydrochloride.J R Coll Gen Pract1974; 24: 411–12
21.
MacDonaldJ.D.. Treatment of multiple sclerosis.J R Coll Gen Pract1974; 24: 853–9
22.
GoreM., BuckmanR., SternG.. Intrathecal cytarabine in multiple sclerosis.Lancet1979; ii: 204
23.
AbbJ., DeinhardtF., ZaderH.Trial of interferon therapy in multiple sclerosis.J Infect Dis1982; 146: 109–15
24.
BarnesM.P., BatesD., CartlidgeN.E., FrenchJ.M., ShawD.A.. Hyperbaric oxygen and multiple sclerosis: short term results of a placebo-controlled double-blind trial.Lancet1985; i: 297–300
25.
PlautG.S.. Hyperbaric oxygen.Lancet1985; i: 573
26.
GalbraithA.W.. Influenza; recent developments in prophylaxis and treatment.Br Med Bull1985; 41: 381–5
27.
GalbraithA.W.. Prevention of post herpetic neuralgia by Amantadine.Br J Clin Pract1983; 37: 304–6
28.
KurtzkeJ.F.. On the evaluation of disability of multiple sclerosis.Neurology1961; 11: 686–94
29.
SegalA.W.. Variation on the theme of chronic granulomatous disease.Lancet1985; ii: 1378–82
30.
SibleyW.A.. Clinical viral infection and multiple sclerosis.Lancet1984; i: 1313–15
31.
Dowling StJ.. Lourdes cures and their medical assessment.J R Soc Med1984; 77: 634–8
32.
PlautG.S.. Telling about multiple sclerosis.Lancet1985; ii: 159
33.
MaloneP.R., StantonS.L., RiddleP.R.. Urinary diversion for incontinence.Ann R Coll Surg1985; 67: 349–52
