Severe Adrenal Suppression by Steroid Nasal Drops

Wilson A.M. , Sims E.J. , Lipworth BJ. Dose response with fluticasone propionate on adrenocortical activity and recovery of basal and stimulated responses after stopping treatment. Clin Endocrinol 1999; 50: 329–34

Findaly C.A. , Macdonald J.F. , Wallace A.M. , Geddes N. , Donaldson MDC. Childhood Cushing's syndrome induced by betamethasone nose drops and repeat prescriptions. BMJ 1998; 317: 739–40

Daman Willems C.E. , Dinwiddie R. , Grant D.B. , Rivers R.P. , Kahir M. Temporary inhibition of growth and adrenal suppression associated with the use of steroid nose drops. Eur J Pediatr 1994; 153: 632–4

Heroman W.M. , Bybee D.E. , Cardin M.J. , Bass J.W. , Johnsonbaugh RE. Adrenal suppression and Cushingoid changes secondary to dexamethasone nose drops. J Pediatr 1980; 96: 500–1

Nutting C.M. , Page SR. Iatrogenic Cushing's syndrome due to nasal betamethasone: a problem not to be sniffed at! Postgrad Med J 1995; 71: 231–2

Stevens DJ. Cushing's syndrome due to the abuse of betamethasone nasal drops. J Laryngol Otol 1988; 102: 219–21

Kimmerle R. , Rolla AR. Iatrogenic Cushing's syndrome due to dexamethasone nasal drops. Am J Med 1985; 79: 535–7

Gallagher G. , Mackay I. Doctors and drops. BMJ 1991; 303: 761

Weiner J.M. , Abramson M.J. , Puy RM. Intranasal corticosteroids versus H₁ receptor antagonists in allergic rhinitis: systematic review of randomised controlled trials. BMJ 1998; 317: 6124–9

Brannan M.D. , Herron J.M. , Reidenberg P. , Affrime MB. Lack of hypothalamic-pituitary-adrenal axis suppression with once-daily or twice-daily beclomethasone dipropionate aqueous nasal spray administered to patients with allergic rhinitis. Clin Ther 1995; 17: 637–47

Gaziz A.G. , Homer J.J. , Page S. , Jones NS. The effect of topical nasal betamethasone drops for nasal polyposis on adrenal function. Clin Otol 1998; 23: 280