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Abstract

Monitoring of two-armed clinical trials using group sequential methods has been implemented for over a dozen years. This paper considers analogous monitoring procedures for multi-armed clinical trials. Monitoring the trial based on repeated tests of a global null hypothesis, monitoring of comparisons of several treatments to a control, and monitoring of all pairwise comparisons are considered. The procedure of choice for a given situation will depend on how the application at hand is best formulated.

Keywords

Group sequential monitoring Multi-armed clinical trials

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