A new paradigm is needed for successful pharmaceutical research. The systems approach, a broad, holistic approach that integrates laboratory and computational approaches, is proposed as a candidate for this paradigm. The use of this approach will provide a more rational means of understanding disease mechanisms and finding how to target these mechanisms pharmacologically.
ZiaiMRBeerB.Making business sense of science with rational drug design. Pharmaceutical Executive.1990;10(10):40,42,44,46.
2.
FrostHM. An optimizing strategy for skeletal research. In: FrostHM, Intermediary Organization of the Skeleton, Vol. II, Chapter 14. Boca Raton, FL; CRC Press; 1986: 197–210.
3.
TuckerR.Essay: ‘Holographic’ science to meet energy needs. Scientific American, March 1990.
4.
von BertalanffyL.General System Theory. New-York: George Braziller; 1968.
5.
RahitzH.Systems analysis at the molecular scale. Science.1989;246: 221–226.
6.
LacyME. Systems theory as a conceptual and organizational framework for computational and inferential chemistry. J Chem Educ.1986;63: 392–396.
7.
GiarrussoF.Windows of information. Today's Chemist, October 1990.
8.
LacyME. Letter: Missing the point [scope of computational biology]. Nature.1991;351: 434.
9.
LacyME. Artificial laboratories. AI Magazine.1989;10(2):43–48.
