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Abstract

A case of cholestatic jaundice appearing after administration of chlorpromazine is analyzed using the Bayesian method. This analysis indicates a high probability of drug causation. The analysis illustrates the relative importance of the background and case information in making the differential diagnosis between drug and nondrug etiologics.

Keywords

Cholestatic jaundice Drug-induced cholestasis Chlorpromazine Bayesian causality assessment

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References

Zimmerman

: Psychotropic and anticonvulsant agents, Chapter 18. In Zimmerman

(ed): Hepatotoxicity: Adverse Effects of Drugs and Other Chemicals on the Liver. New York, Appleton-Century-Crofts, 1978.

A Bayesian Approach to Assessment of Adverse Drug Reactions: Evaluation of a Case of Cholestatic Jaundice

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