Efficacy of single dose albendazole and praziquantel drugs among helminth-infected school children at Rural Bahir Dar,northwest Ethiopia

Abstract

The resistance of anthelminthic drugs makes helminth control difficult. The aim of our study was to assess the efficacy of single dose albendazole and praziquantel drugs among helminth-infected children. A cross-sectional study was conducted from April to June, 2017. Stool examination was done by the Formol-Ether concentration technique. Students infected with geohelminths and schistosoma mansoni were treated with a single dose of albendazole and praziquantel, respectively. Post-treatment stool examination was performed after two weeks. The magnitude of parasite infection, percentage of egg count reduction and cure rate following treatment were calculated using descriptive statistics.

A total of 409 Sebatamet primary school students were included. The total prevalence of intestinal parasitosis was 58%. The cure rate of albendazole against hookworm was only 76.8%. Praziquantel had a 91.4% cure rate against Schistosoma mansoni. Therefore, periodic evaluation of the efficacy of anthelminthic drugs is required.

Keywords

Efficacy albendazole praziquantel hookworm schistosomia mansoni

Get full access to this article

View all access options for this article.

References

World Health Organization. Prevention and Control of Intestinal Parasitic Infections. WHO Technical Report Series 741. Geneva: WHO, 1987.

Keiser

Utzinger

. The drugs we have and the drugs we need against major helminth infections. Adv Parasitol 2000; 73: 197–230.

Brooker

Hotez

Bundy

. The global atlas of helminth infection: mapping the way forward in neglected tropical disease control. PLoS Negl Trop Dis 2010; 4: e779–e779.

Siddiqui

Siddiquid

Ganley-Leal

. Schistosomiasis vaccines. Hum Vaccines 2011; 7: 1192–1197.

Ross

Bartley

Sleigh

et al.

Schistosomiasis. N Engl J Med 2002; 346: 1212–1220.

Leykun

. Soil transmitted helminthic infection and S. mansoni in school children from Chilga District, North West Ethiopia. Ethiop J Health Sci 2001; 11: 79–87.

Obiamuiwe

Nmorsi

. Human gastro-intestinal parasites in Bendel State, Nigeria. Angew Parasitol 1991; 32: 177–183.

Nokes

Cooper

Robinson

et al.

Geohelminth infection and academic assessment in Jamaican children. Trans R Soc Trop Med Hyg 1991; 85: 272–273.

Albonico

Allen

Chitsulo

et al.

Controlling soil-transmitted helminthiasis in pre-school-age children through preventive chemotherapy. PLoS Negl Trop Dis 2008; 2: e126–e126.

10.

Bennett

Guyatt

. Reducing intestinal nematode infection: efficacy of albendazole and mebendazole. Parasitol Today 2000; 16: 71–74.

11.

Gryseels

Mbaye

De Vlas

et al.

Are poor responses to praziquantel for the treatment of Schistosomamansoni infections in Senegal due to resistance? An overview of the evidence. Trop Med Int Health 2001; 6: 864–873.

12.

Soukhathammavong

Sayasone

Phongluxa

et al.

Low efficacy of single-dose albendazole and mebendazole against hookworm and effect on concomitant helminth infection in Lao PDR. PLoS Negl Trop Dis 2012; 6: e1417–e1417.

13.

Kataz

Rocha

De Soza

et al.

Efficacy of alternating therapy with oxamiquine and praziquantel to treat. S. mansoni in children following failure of first treatment. Am J Trop Med Hyg 1999; 44: 509–512.

14.

Stelma

Talla

Sow

et al.

Efficacy and side effects of Praziquantel in an epidemic focus of Schistosoma mansoni. Am J Trop Med Hyg 1995; 53: 167–170.

15.

Wolstenholme

Fairweather

Prichard

et al.

Drug resistance in veterinary helminthes. Trends Parasitol 2004; 20: 469–476.