An increase in the level of plasma fibrinogen is associated with occlusive arterial diseases, venous thrombo-embolism and may precede disseminated intravascular coagulation. In addition fibrinogen levels may be predictive of fatal coronary artery disease and post-operative venous thrombosis. It is possible that fibrinogen may produce its effects by increase in blood and plasma viscosity, by arterial wall infiltration or by its effects on platelet function. Acute reduction in fibrinogen levels by ancrod (Arvin) alters all these parameters and may return them to normal. As yet no study has been carried out with long term reduction of fibrinogen by stanozolol but this is now feasible and such a trial is indicated.
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