People experiencing homelessness (PEH) face more mental health-related problems and a worse quality of life (QoL) than the general population. This research aimed to know the repercussion of a psychosocial healthcare program with PEH using mobile phones. This quasi-experimental study previously and subsequently evaluated interventions with 30 users (Complete Intervention = 23; Partial Intervention = 7) at 3 and 6 months. They periodically attended two municipal shelters for PEH.. At 3 months, those who did the complete intervention presented significant improvements in self-perceived QoL, with this significance moving toward anxiety/depression and responsible alcohol consumption. Those who completed the study indicated a high degree of satisfaction with it and adhered to scheduled appointments. The PEH who adhered to the study obtained a better initial psychosocial evaluation than those who dropped out. Thus, future studies with more participants would clear up doubts about the tendency of the variables that improved in this study. We recommend healthcare professionals to go directly to where PEH are and to set up mobile phone follow-up because PEH’s personal conditions do not allow them to go to mental health appointments.
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