Epigenetic research has pointed to that the interaction between genetics and environmental factors may play a role in making some individuals more vulnerable than others.
Aim
The aim of this article was to present a broad perspective on the current state of knowledge in a relatively new and complex field of “attachment and epigenetic processes.”
Method
We conducted a scoping review based on a systematic literature search in PsycINFO, PubMed, and Embase databases for relevant abstracts using the terms attachment and epigenet*.
Results
In total, 11 studies were included. Research predating 2009 and animal studies were excluded in order to review the current state of research in humans.
Conclusion
Overall, there seems to be a consistency in the literature, pointing to a link between early childhood adversity, attachment processes, and epigenetic changes. However, research in human subjects is still limited.
AinsworthM.BleharM.WatersE.WallS. (1978). Patterns of attachment: A psychological study of the strange situation.
Mahwah, NJ:
Lawrence Erlbaum Associates.
2.
AlhusenJ. L.HayatM. J.GrossD. (2013).
A longitudinal study of maternal attachment and infant developmental outcomes. Archives of Women’s Mental Health,
16(6), 521–529. doi:10.1007/s00737-013-0357-8.A
3.
BartolucciA. A.HillegassW. B. (2010). Overview, strengths, and limitations of systematic reviews and meta-analyses. In ChiappelliM. H.Caldeira BrantF.NeagosX. M.OluwadaraN.RamchandaniO. O. (Eds.), Evidence-based practice: Toward optimizing clinical outcomes (pp. 17–33).
Berlin, Heidelberg:
Springer. doi:10.1007/978-3-642-05025-1
4.
BosmansG.YoungJ. F.HankinB. L. (2018).
NR3C1 methylation as a moderator of the effects of maternal support and stress on insecure attachment development. Developmental Psychology,
54(1), 29–38. doi:10.1037/dev0000422
5.
BowlbyJ. (1958).
The nature of the child’s tie to his mother. The International Journal of Psycho-Analysis,
39, 350–373.
BowlbyJ. (1960b).
Separation anxiety. The International Journal of Psycho-Analysis,
41, 89–113.
8.
BuchheimaA.HeinrichsM.GeorgeC.PokornyD.KoopsE.HenningsenP.GündelH. (2009).
Oxytocin enhances the experience of attachment security. Psychoneuroendocrinology,
34(9), 1417–1422. doi:10.1016/j.psyneuen.2009.04.002
9.
BuhrmesterD.FurmanW. (1985).
Children’s perceptions of the personal relationships in their social networks. Developmental Psychology,
21(6), 1016–1024.
10.
CappiC.DinizJ. B.RequenaG. L.LourençoT.LisboaB. C. G.BatistuzzoM. C.BrentaniH. (2016).
Epigenetic evidence for involvement of the oxytocin receptor gene in obsessive-compulsive disorder. BMC Neuroscience,
17(1), 79. doi:10.1186/s12868-016-0313-4
11.
ChoeD. E.OlsonS. L.SameroffA. J. (2013).
Effects of early maternal distress and parenting on the development of children’s self-regulation and externalizing behavior. Development and Psychopathology,
25(2), 437–453. doi:10.1017/S0954579412001162
12.
Darling RasmussenP.StorebøO. J.LøkkeholtT.VossL. G.Shmueli-GoetzY.BojesenA. B.BilenbergN. (2018).
Attachment as a core feature of resilience: A systematic review and meta-analysis. Psychological Reports,
122(4), 1259–1296. doi:10.1177/0033294118785577
13.
Darling RasmussenP.StorebøO. J.Shmueli-GoetzY.SimonsenE.BojesenA. B.BilenbergN. (2019, February).
Attachment representations in mothers and their children diagnosed with ADHD: Distribution, transmission and impact on treatment outcome. Journal of Child and Family Studies,
28(4), 1018–1028.
14.
DaudtH. M. L.Van MosselC.ScottS. J. (2013).
Enhancing the scoping study methodology: A large, inter-professional team’s experience with Arksey and O’Malley’s framework. BMC Medical Research Methodology,
13(1), 1–9. doi:10.1186/1471-2288-13-48
15.
DeansC.MaggertK. A. (2015).
What do you mean, “Epigenetic”?Genetics,
199(4), 887–896. doi:10.1534/genetics.114.173492
16.
EbnerN. C.LinT.MuradogluM.WeirD. H.PlasenciaG. M.LillardT. S.ConnellyJ. J. (2019).
Associations between oxytocin receptor gene (OXTR) methylation, plasma oxytocin, and attachment across adulthood. International Journal of Psychophysiology,
136, 22–32. doi:10.1016/j.ijpsycho.2018.01.008
17.
Ein-DorT.VerbekeW. J. M. I.MokryM.VrtičkaP. (2018).
Epigenetic modification of the oxytocin and glucocorticoid receptor genes is linked to attachment avoidance in young adults. Attachment and Human Development,
20(4), 439–454. doi:10.1080/14616734.2018.1446451
18.
ElmadihA.AbumadiniM. (2019).
Epigenetic transmission of maternal behavior: Impact on the neurobiological system of healthy mothers. Saudi Journal of Medicine and Medical Sciences,
7(1), 3–8. doi:10.4103/sjmms.sjmms_163_17
19.
FerrariR. (2015).
Writing narrative style literature reviews correspondence to. Medical Writing,
24(4), 230–235. doi:10.1179/2047480615Z.000000000329
20.
FonagyP.TargetM. (2005).
Bridging the transmission gap: An end to an important mystery of attachment research?Attachment & Human Development,
7(3), 333–343. doi:10.1080/14616730500269278
21.
GervaiJ. (2009).
Environmental and genetic influences on early attachment. Child and Adolescent Psychiatry and Mental Health,
3, 25. doi:10.1186/1753-2000-3-25
22.
Grad, F. P. (2002). The preamble of the Constitution of the World Health Organization: public health classics/Frank P. Grad. Bulletin of the World Health Organization: the International Journal of Public Health, 80(12) : 981–984.
23.
GreenB. N.JohnsonC. D.AdamsA. (2006).
Writing narrative literature reviews for peer-reviewed journals: Secrets of the trade. Journal of Chiropractic Medicine,
5(3), 101–117. doi:10.1162/LING_a_00246
24.
HaasB. W.FilkowskiM. M.CochranR. N.DenisonL.IshakA.NishitaniS., … SmithA. K. (2016).
Epigenetic modification of OXT and human sociability. Proceedings of the National Academy of Sciences of the United States of America,
113(27), E3816–E3823. doi:10.1073/pnas.1602809113
25.
HankinB.AbramsonL. (2002).
Measuring cognitive vulnerability to depression in adolescence: Reliability, validity, and gender differences. Journal of Clinical Child & Adolescent Psychology,
31(3), 491–504.
26.
Hazan, C., & Shaver, P. (1987). Romantic love conceptualized as an attachment process. Journal of Personality and Social Psychology, 52(3), 511–524.
27.
Jones-MasonK.AllenI. E.BushN.HamiltonS. (2016).
Epigenetic marks as the link between environment and development: Examination of the associations between attachment, socioeconomic status, and methylation of the SLC6A4 gene. Brain and Behavior,
6(7), e00480. doi:10.1002/brb3.480
28.
KochanskaG.KimS. (2013).
Difficult temperament moderates links between maternal responsiveness and children’s compliance and behavior problems in low-income families. Journal of Child Psychology Psychiatry,
54(3), 323–332. doi:10.1111/jcpp.12002.
29.
LawnR. B.AndersonE. L.SudermanM.SimpkinA. J.GauntT. R.TeschendorffA. E.HoweL. D. (2018).
Psychosocial adversity and socioeconomic position during childhood and epigenetic age: Analysis of two prospective cohort studies. Human Molecular Genetics,
27(7), 1301–1308. doi:10.1093/hmg/ddy036
30.
LevacD.ColquhounH.O’BrienK. K. (2010).
Scoping studies: Advancing the methodology. Implementation Science,
5(69), 1–9. doi:10.1186/1748-5908-5-69
31.
McWilliamsL. A.BaileyS. J. (2010).
Associations between adult attachment ratings and health conditions: Evidence from the national comorbidity survey replication. Health Psychology,
29(4), 446–453. doi:10.1037/a0020061
32.
MulderR. H.RijlaarsdamJ.LuijkM. P. C. M.VerhulstF. C.FelixJ. F.TiemeierH.Van IjzendoornM. H. (2017).
Methylation matters: FK506 binding protein 51 (FKBP5) methylation moderates the associations of FKBP5 genotype and resistant attachment with stress regulation. Development and Psychopathology,
29(2), 491–503. doi:10.1017/S095457941700013X
33.
MurgatroydC.SpenglerD. (2011, April).
Epigenetics of early child development. Frontiers in Psychiatry,
2, 16. doi:10.3389/fpsyt.2011.00016
34.
NagyC.TureckiG. (2012).
Sensitive periods in epigenetics: Bringing us closer to complex behavioral phenotypes. Epigenomics,
4(4), 445–457. doi:10.2217/epi.12.37
35.
NolteT.GuineyJ.FonagyP.MayesL. C.LuytenP. (2011, September).
Interpersonal stress regulation and the development of anxiety disorders: An attachment-based developmental framework. Frontiers in Behavioral Neuroscience,
5, 55. doi:10.3389/fnbeh.2011.00055
36.
PetersonJ.PearceP. F.FergusonL. A.LangfordC. A. (2016).
Understanding scoping reviews. Journal of the American Association of Nurse Practitioners,
29(1), 12–16. doi:10.1002/2327-6924.12380
37.
PrevattF. F. (2003).
The contribution of parenting practices in a risk and resiliency model of children’s adjustment. British Journal of Developmental Psychology,
21, 469–480. doi:10.1348/026151003322535174
38.
PuigJ.EnglundM. M.SimpsonJ. A.CollinsW. A. (2013).
Predicting adult physical illness from infant attachment: A prospective longitudinal study. Health Psychology,
32(4), 409–417. doi:10.1037/a0028889
39.
RudolphK. D.FlynnM. (2007).
Childhood adversity and youth depression: Influence of gender and pubertal status. Development and Psychopathology,
19(2), 497–521. doi:10.2217/FON.09.6.Dendritic
40.
SchechterD. S.MoserD. A.PointetV. C.AueT.StenzL.Paoloni-GiacobinoA.DayerA. G. (2017).
The association of serotonin receptor 3A methylation with maternal violence exposure, neural activity, and child aggression. Behavioural Brain Research,
325(Pt B), 268–277. doi:10.1016/j.bbr.2016.10.009
41.
SchoreA. N. (2001).
Effects of a secure attachment relationship on right brain development, affect regulation, and infant mental health. Infant Mental Health Journal,
22(1–2), 7–66. doi:10.1002/1097-0355(200101/04)22:1<7::AID-IMHJ2>3.0.CO;2-N
42.
SchoreJ. R.SchoreA. N. (2008).
Modern attachment theory: The central role of affect regulation in development and treatment. Clinical Social Work Journal,
36(1), 9–20. doi:10.1007/s10615-007-0111-7
43.
SeayB.HansenE.HarlowH. F. (1962).
Mother-infant separation in monkeys. Journal of Child Psychology and Psychiatry,
3(3–4), 123–132. doi:10.1111/j.1469-7610.1962.tb02047.x
44.
StorebøO. J.Darling RasmussenP.SimonsenE. (2013).
Association between insecure attachment and ADHD: Environmental mediating factors. Journal of Attention Disorders,
20(2), 187–196. doi:10.1177/1087054713501079
45.
TammenS. A.FrisoS.ChoiS. W. (2013).
Epigenetics: The link between nature and nurture. Molecular Aspects of Medicine,
34(4), 753–764. doi:10.1016/j.mam.2012.07.018
46.
TopsM.Van PeerJ. M.KorfJ.WijersA. A.TuckerD. M. (2007).
Anxiety, cortisol, and attachment predict plasma oxytocin. Psychophysiology,
44(3), 444–449.
47.
TyrkaA. R.PriceL. H.MarsitC.WaltersO. C.CarpenterL. L. (2012).
Childhood adversity and epigenetic modulation of the leukocyte glucocorticoid receptor: Preliminary findings in. Archives of Family Medicine,
7(1), 1–8. doi:10.1371/journal.pone.0030148
48.
UnternaehrerE.MeyerA. H.BurkhardtS. C. A.DempsterE.StaehliS.TheillN.MeinlschmidtG. (2015).
Childhood maternal care is associated with DNA methylation of the genes for brain-derived neurotrophic factor (BDNF) and oxytocin receptor (OXTR) in peripheral blood cells in adult men and women. Stress,
18(4), 451–461. doi:10.3109/10253890.2015.1038992
49.
Van IJzendoornM. H., & Bakermans-KranenburgM. J. (1996).
Attachment representations in mothers, fathers, adolescents, and clinical groups: A meta-analytic search for normative data. Journal of Consulting and Clinical Psychology,
64(1), 8–21. doi:10.1037/0022-006X.64.1.8
50.
Van IjzendoornM. H.Bakermans-KranenburgM. J. (1997). Intergenerational transmission of attachment: A move to the contextual level. In AtkinsonL.ZuckerK. J. (Eds.), Attachment and Psychopathology (pp. 135–170).
New York, NY:
Guilford Press.
51.
Van IJzendoornM. H.CaspersK.Bakermans-KranenburgM. J.BeachR. H.PhilibertR. (2010).
Methylation matters: Interaction between methylation density and 5HTT genotype predicts unresolved loss or trauma. Biological Psychiatry,
68(5), 405–407. doi:10.1016/j.biopsych.2010.05.008.Methylation
52.
WeaverI. C. G. (2009).
Epigenetic effects of glucocorticoids. Seminars in Fetal and Neonatal Medicine,
14(3), 143–150. doi:10.1016/j.siny.2008.12.002
53.
WeaverI. C. G.MeaneyM. J.SzyfM. (2006).
Maternal care effects on the hippocampal transcriptome and anxiety-mediated behaviors in the offspring that are reversible in adulthood. Proceedings of the National Academy of Sciences of the United States of America,
103(9), 3480–3485. doi:10.1073/pnas.0507526103
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