Restricted accessResearch articleFirst published online 2018-2
Successful Goal-Directed Memory Suppression is Associated With Increased Inter-Hemispheric Coordination Between Right and Left Frontoparietal Control Networks
The neural basis of suppressing conscious access to one’s own memories has recently received considerable attention, with several studies suggesting this process engages frontal-parietal cognitive control regions. However, researchers to date have not examined the way right and left hemisphere cognitive control networks coordinate with one another to accomplish this. We had 48 participants (25 female) complete a Think/No Think (T/NT) task for memories of emotionally unpleasant visual scenes while undergoing functional magnetic resonance imaging. We used generalized psychophysiologic interaction analyses to examine functional connectivity between right and left hemisphere frontal-parietal regions during memory suppression. Participants who were better at memory suppression, as assessed by greater numbers of forgotten memories in the NT than T conditions, also showed greater functional connectivity between multiple right and left hemisphere control regions. This suggests that individual differences in memory suppression ability may be partially explained by differences in task-specific inter-hemispheric coordination.
AndersonM.GreenC. (2001) Suppressing unwanted memories by executive control. Nature410(6826): 366–369. Retrieved from http://doi.org/10.1038/35066572.
2.
AndersonM.HanslmayrS. (2014) Neural mechanisms of motivated forgetting. Trends in Cognitive Sciences18(6): 279–282. Retrieved from http://doi.org/10.1016/j.tics.2014.03.002.
3.
AndersonM.OchsnerK.KuhlB.CooperJ.RobertsonE.GabrieliS.GabrieliJ. (2004) Neural systems underlying the suppression of unwanted memories. Science303(5655): 232–235. Retrieved from http://doi.org/10.1126/science.1089504.
4.
BenoitR.AndersonM. (2012) Opposing mechanisms support the voluntary forgetting of unwanted memories. Neuron76(2): 450–460. Retrieved from http://doi.org/10.1016/j.neuron.2012.07.025.
5.
BenoitR.HulbertJ.HuddlestonE.AndersonM. (2015) Adaptive top-down suppression of hippocampal activity and the purging of intrusive memories from consciousness. Journal of Cognitive Neuroscience27(1): 96–111. Retrieved from http://doi.org/10.1162/jocn_a_00696.
6.
BergströmZ.de FockertJ.Richardson-KlavehnA. (2009) ERP and behavioural evidence for direct suppression of unwanted memories. NeuroImage48(4): 726–737. Retrieved from http://doi.org/10.1016/j.neuroimage.2009.06.051.
7.
ButlerA.JamesK. (2010) The neural correlates of attempting to suppress negative versus neutral memories. Cognitive, Affective, & Behavioral Neuroscience10(2): 182–194. Retrieved from http://doi.org/10.3758/CABN.10.2.182.
8.
CatarinoA.KüpperC.Werner-SeidlerA.DalgleishT.AndersonM. (2015) Failing to forget: Inhibitory-control deficits compromise memory suppression in posttraumatic stress disorder. Psychological Science26(5): 604–16. Retrieved from http://doi.org/10.1177/0956797615569889.
9.
CavannaA.TrimbleM. (2006) The precuneus: A review of its functional anatomy and behavioural correlates. Brain129(Pt 3): 564–583. Retrieved from http://doi.org/10.1093/brain/awl004.
10.
ChenC.LiuC.HuangR.ChengD.WuH.XuP.LuoY.-J. (2012) Suppression of aversive memories associates with changes in early and late stages of neurocognitive processing. Neuropsychologia50(12): 2839–2848. Retrieved from http://doi.org/10.1016/j.neuropsychologia.2012.08.004.
11.
DehaeneS. (2014) Consciousness and the Brain, New York, NY: Viking Press.
12.
DepueB. (2012) A neuroanatomical model of prefrontal inhibitory modulation of memory retrieval. Neuroscience and Biobehavioral Reviews36(5): 1382–1399. Retrieved from http://doi.org/10.1016/j.neubiorev.2012.02.012.
13.
DepueB.BanichM.CurranT. (2006) Suppression of emotional and nonemotional content in memory: Effects of repetition on cognitive control. Psychological Science17(5): 441–447. Retrieved from http://doi.org/10.1111/j.1467-9280.2006.01725.x.
14.
DepueB.CurranT.BanichM. (2007) Prefrontal regions orchestrate suppression of emotional memories via a two-phase process. Science317(5835): 215–219. Retrieved from http://doi.org/10.1126/science.1139560.
15.
EllardK.BarlowD.Whitfield-GabrieliS.GabrieliJ.DeckersbachT. (2017) Neural correlates of emotion acceptance vs worry or suppression in generalized anxiety disorder. Social Cognitive and Affective Neuroscience3(1): 2–17. Retrieved from http://doi.org/10.1093/scan/nsx025.
16.
GagnepainP.HensonR.AndersonM. (2014) Suppressing unwanted memories reduces their unconscious influence via targeted cortical inhibition. Proceedings of the National Academy of Sciences of the United States of America111(13): E1310–E1319. Retrieved from http://doi.org/10.1073/pnas.1311468111.
17.
GitelmanD.PennyW.AshburnerJ.FristonK. (2003) Modeling regional and psychophysiologic interactions in fMRI: The importance of hemodynamic deconvolution. NeuroImage19(1): 200–207. Retrieved from http://doi.org/10.1016/S1053-8119(03)00058-2.
18.
KellerJ.HeddenT.ThompsonT.AnteraperS. A.GabrieliJ.Whitfield-GabrieliS. (2015) Resting-state anticorrelations between medial and lateral prefrontal cortex: Association with working memory, aging, and individual differences. Cortex64: 271–280. Retrieved from http://doi.org/10.1016/j.cortex.2014.12.001.
19.
KimK.YiD.-J. (2013) Out of mind, out of sight: Perceptual consequences of memory suppression. Psychological Science24(4): 569–574. Retrieved from http://doi.org/10.1177/0956797612457577.
20.
KuhlB.DudukovicN.KahnI.WagnerA. (2007) Decreased demands on cognitive control reveal the neural processing benefits of forgetting. Nature Neuroscience10(7): 908–914. Retrieved from http://doi.org/10.1038/nn1918.
21.
LambertA.GoodK.KirkI. (2010) Testing the repression hypothesis: Effects of emotional valence on memory suppression in the think—No think task. Consciousness and Cognition19(1): 281–293. Retrieved from http://doi.org/10.1016/j.concog.2009.09.004.
22.
LangP.BradleyM.CuthbertB. (2008) International affective picture system (IAPS): Affective ratings of pictures and instruction manual (Technical Report A-8), Gainesville, FL: University of Florida.
23.
LevyB.AndersonM. (2012) Purging of memories from conscious awareness tracked in the human brain. The Journal of Neuroscience32(47): 16785–1694. Retrieved from http://doi.org/10.1523/JNEUROSCI.2640-12.2012.
24.
LundstromB.PeterssonaK.AnderssonaJ.JohanssoneM.FranssonaP.IngvarM. (2003) Isolating the retrieval of imagined pictures during episodic memory: Activation of the left precuneus and left prefrontal cortex. NeuroImage20(4): 1934–1943. Retrieved from http://doi.org/10.1016/j.neuroimage.2003.07.017.
25.
McLarenD.RiesM.XuG.JohnsonS. (2012) A generalized form of context-dependent psychophysiological interactions (gPPI): A comparison to standard approaches. NeuroImage61(4): 1277–1286. Retrieved from http://doi.org/10.1016/j.neuroimage.2012.03.068.
26.
MurrayB.MuscatellK.KensingerE. (2011) Effects of emotion and age on performance during a think/no-think memory task. Psychology and Aging26(4): 940–955. Retrieved from http://doi.org/10.1037/a0023214.
27.
NørbyS.LangeM.LarsenA. (2010) Forgetting to forget: On the duration of voluntary suppression of neutral and emotional memories. Acta Psychologica133(1): 73–80. Retrieved from http://doi.org/10.1016/j.actpsy.2009.10.002.
28.
Paz-AlonsoP.BungeS.AndersonM.GhettiS. (2013) Strength of coupling within a mnemonic control network differentiates those who can and cannot suppress memory retrieval. The Journal of Neuroscience33(11): 5017–5026. Retrieved from http://doi.org/10.1523/JNEUROSCI.3459-12.2013.
29.
RuggM.VilbergK. (2013) Brain networks underlying episodic memory retrieval. Current Opinion in Neurobiology23(2): 255–260. Retrieved from http://doi.org/10.1016/j.conb.2012.11.005.
30.
SmithR.AlkozeiA.LaneR.KillgoreW. (2016) Unwanted reminders: The effects of emotional memory suppression on subsequent neuro-cognitive processing. Consciousness and Cognition44: 103–113. Retrieved from http://doi.org/10.1016/j.concog.2016.07.008.
31.
van SchieK.GeraertsE.AndersonM. (2013) Emotional and non-emotional memories are suppressible under direct suppression instructions. Cognition & Emotion27(6): 1122–1131. Retrieved from http://doi.org/10.1080/02699931.2013.765387.
32.
WaldhauserG. T.BäumlK.-H. T.HanslmayrS. (2015) Brain oscillations mediate successful suppression of unwanted memories. Cerebral Cortex25(11): 4180–4190. Retrieved from http://doi.org/10.1093/cercor/bhu138.
33.
Whitfield-GabrieliS.Nieto-CastanonA. (2012) Conn: A functional connectivity toolbox for correlated and anticorrelated brain networks. Brain Connectivity2(3): 125–141. Retrieved from http://doi.org/10.1089/brain.2012.0073.
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