Cade oil is distilled from the branches and wood of Juniperus oxycedrus. It is widely used in traditional medicine in Morocco and is also widely available and promoted on Amazon. It is potentially particularly poisonous to children, the incidence of which is on the rise. Phenol is the most toxic component responsible for most systemic signs. We hereby report the fatal cases of three infants who had cade oil applied topically to treat diarrhoea, vomiting and fever.
NgWYHungLYLamYH, et al.
Poisoning by toxic plants in Hong Kong: a 15-year review. Hong Kong Med J Xianggang Yi Xue Za Zhi2019;
25(2): 102–112.
5.
SlaughterRJBeasleyDMGLambieBS, et al.
Poisonous plants in New Zealand: a review of those that are most commonly enquired about to the National Poisons Centre. N Z Med J2012;
125(1367): 87–118.
6.
RhalemNKhattabiAAchourS, et al. Intoxications par les plantes et les produits de la pharmacopée traditionnelle au Maroc. 2022; (54): 16.
7.
KhanIAAbourashedEA.Leung’s encyclopedia of common natural ingredients used in food, drugs, and cosmetics. Third Edition. Hoboken, New Jersey: John Wiley, 2010.
8.
OgataNToyodaMShibataT.Suppression of intestinal smooth muscle contraction by phenolic compounds. Res Commun Chem Pathol Pharmacol1992;
77(3): 359–366.
9.
DiğrakMIlçimAHakki AlmaM.Antimicrobial activities of several parts of Pinus brutia, Juniperus oxycedrus, Abies cilicia, Cedrus libani and Pinus nigra. Phytother Res PTR1999;
13(7): 584–587.
10.
EzzakiIFSMtiouiNKhayatSE, et al.
Acute renal failure following poisoning by juniper tar (cade oil). J Clin Toxicol2020;
10(4): 1–2.
11.
LakhdarKBerdaiMABenlamkademSLabibSHarandouM.
Cade oil poisoning: about a case. Med Sante Trop2019;
29(1): 110–111.
12.
SkalliSChebatABadraneN, et al.
Side effects of cade oil in Morocco: an analysis of reports in the Moroccan herbal products database from 2004 to 2012. Food Chem Toxicol Int J Publ Br Ind Biol Res Assoc2014;
64: 81–85.
13.
BebanaDBen MekhtariH.Caractérisation physico-chimique d’huile de cade traditionnelle [Obtention du diplôme de master].
[Algérie]:
Ahmed Draia Adrar, 2022.
14.
HalmouneM. Les intoxications aigues aux plantes en réanimation pédiatrique [obtention du doctorat en médecine]. [Fès]: Sidi Mohammed ben abdelah, 2022.
15.
ChaïmaeSEch-ChebabMAyyadA, et al.
Fatal neonatal intoxication from cutaneous cade oil: A case of multivisceral failure. Cureus2024;
16(7): e65133.
16.
ErraghABellaftouhSAfifA, et al.
Cade oil poisoning: A case series. Case Rep Clin Med2023;
12(06): 159–167.
17.
AziziMEl KaouiniALafkihMA, et al.
A rare case of cade oil poisoning complicated by acute pancreatitis and acute tubular necrosis. Ann Med Surg2012;
76: 103562.
18.
KorukSTOzyilkanEKayaP, et al.
Juniper tar poisoning. Clin Toxicol Phila Pa2005;
43(1): 47–49.
19.
BoubekriABentalhaAAtmaniW, et al. Adverse effects of topical cade oil in a case report. Austin Pediatr. 2023; 10(1): 1081.
20.
AchiMHaddariFBelmkeddemS, et al. Intoxication A L’huile De Cade A propos D’un Cas Cade Oil Intoxication In A Case. IOSR Journal of Nursing and Health Science 2021; 10(4): 9–11.
21.
HoummaniHSahliMYChebatA, et al.
Intoxication infantile au juniperus oxycedrus (huile de cade): à propos de 4 décès. Toxicol Anal Clin2019;
31(2): 129–133.
22.
AchourSAbourazzakSMokhtariA, et al.
Juniper tar (cade oil) poisoning in new born after a cutaneous application. BMJ Case Rep2011;
2011: bcr0720114427.
