A growing literature has linked religiousness and spirituality (R/S) to substance use and abuse. However, it is not clear that R/S has causal effects on substance use. Currently, there is a relative lack of genetically sensitive examinations in the literature attendant to R/S effects. Given that behavioral genetic analyses have illustrated the influence of genetic factors on substance use and adherence to R/S worldviews, genetic confounding is a concern. The current study employed a sample of monozygotic twins discordant on religiousness, spirituality, and spiritual transformation to assess effects on substance use and abuse. Bivariate and multivariate models indicated a general lack of effect of R/S on substance use and abuse but did illustrate a dampening influence of religiousness on general (but not problematic) alcohol use. The findings highlight the importance of controlling for genetic and shared familial factors in examinations of the religiousness–spirituality–substance use nexus.
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